Optimal nutrition during the period of mechanical ventilation decreases mortality in critically ill, long-term acute female patients a prospective observational cohort study 英文参考文献.docVIP

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Optimal nutrition during the period of mechanical ventilation decreases mortality in critically ill, long-term acute female patients a prospective observational cohort study 英文参考文献.doc

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Optimal nutrition during the period of mechanical ventilation decreases mortality in critically ill, long-term acute female patients a prospective observational cohort study 英文参考文献

Available online /content/13/4/R132 Research Open Access Vol 13 No 4 Optimal nutrition during the period of mechanical ventilation decreases mortality in critically ill, long-term acute female patients: a prospective observational cohort study Rob JM Strack van Schijndel1, Peter JM Weijs2, Rixt H Koopmans1, Hans P Sauerwein3, Albertus Beishuizen1 and Armand RJ Girbes1 1Department of Intensive Care Medicine, VU University Medical Centre, PO Box 7057, 1007 MB Amsterdam, the Netherlands 2Department of Nutrition and Dietetics, VU University Medical Centre, PO Box 7057, 1007 MB Amsterdam, the Netherlands 3Palmgracht 44 B, 1015 HN Amsterdam, the Netherlands Corresponding author: Peter JM Weijs, p.weijs@vumc.nl Received: 16 Mar 2009 Revisions requested: 27 Apr 2009 Revisions received: 9 Jul 2009 Accepted: 11 Aug 2009 Published: 11 Aug 2009 Critical Care 2009, 13:R132 (doi:10.1186/cc7993) This article is online at: /content/13/4/R132 ? 2009 Strack van Schijndel et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Optimal nutrition for intensive care patients has been proposed to be the provision of energy as determined by indirect calorimetry, and protein provision of at least 1.2 g/kg pre-admission weight per day. The evidence supporting these nutritional goals is based on surrogate outcomes and is not yet Results In women, when corrected for weight, height, Apache II score, diagnosis category, and hyperglycaemic index, patients who reached their nutritional goals compared to those who did not, showed a hazard ratio (HR) of 0.199 for ICU mortality (CI 0.048–0.831; P = 0.027), a HR of 0.079 for 28 day mortality (CI 0.013–0.467; P = 0.005) and a HR of 0.328 for hospital mortality (CI 0.113–0