Optical Slot-Waveguide Based Biochemical Sensors 英文参考文献.docVIP

Sensors 2009, 9, 4751-4765; doi:10.3390/OPEN ACCESS sensors ISSN 1424-8220 /journal/sensors Review Optical Slot-Waveguide Based Biochemical Sensors Carlos Angulo Barrios Instituto de Sistemas Optoelectrónicos y Microtecnología (ISOM), ETSI Telecomunicación, Universidad Politécnica de Madrid, Ciudad Universitaria s/n, 28040 Madrid, Spain; E-Mail: carlos.angulo.barrios@upm.es; Tel.: +34 91 5495700; Fax: +34 91 4533567 Received: 27 May 2009; in revised form: 9 June 2009 / Accepted: 15 June 2009 / Published: 16 June 2009 Abstract: Slot-waveguides allow light to be guided and strongly confined inside a nanometer-scale region of low refractive index. Thus stronger light-analyte interaction can be obtained as compared to that achievable by a conventional waveguide, in which the propagating beam is confined to the high-refractive-index core of the waveguide. In addition, slot-waveguides can be fabricated by employing CMOS compatible materials and technology, enabling miniaturization, integration with electronic, photonic and fluidic components in a chip, and mass production. These advantages have made the use of slot- waveguides for highly sensitive biochemical optical integrated sensors an emerging field. In this paper, recent achievements in slot-waveguide based biochemical sensing will be reviewed. These include slot-waveguide ring resonator based refractometric label-free biosensors, label-based optical sensing, and nano-opto-mechanical sensors. Keywords: integrated optics; slot-waveguides; optical sensors; biosensors 1. Introduction Optical sensors are remarkable tools for analyte detection in biochemical, health and environmental applications. The use of photons for sensing makes possible multi-dimension (intensity, wavelength, phase, and polarization) and remote interrogation, immunity to electromagnetic interferences, multiplexed detection,