Pattern Specification and Immune Response Transcriptional Signatures of Pericardial and Subcutaneous Adipose Tissue 英文参考文献.docVIP

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Pattern Specification and Immune Response Transcriptional Signatures of Pericardial and Subcutaneous Adipose Tissue 英文参考文献.doc

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Pattern Specification and Immune Response Transcriptional Signatures of Pericardial and Subcutaneous Adipose Tissue 英文参考文献

PatternSpecificationandImmuneResponse TranscriptionalSignaturesofPericardialand SubcutaneousAdiposeTissue FrankH.Lau1,RahulC.Deo1,GregoryMowrer1,JoshuaCaplin3,TimAhfeldt1,2,AdamKaplan1 ,Leon Ptaszek3,JenniferD.Walker4,BruceR.Rosengard4,ChadA.Cowan1,2* 1CenterforRegenerativeMedicineandCardiovascularResearchCenter,MassachusettsGeneralHospital,Boston,Massachusetts,UnitedStatesofAmerica,2Department ofStemCellandRegenerativeBiology,HarvardStemCellInstitute,HarvardUniversity, Cambridge,Massachusetts, UnitedStatesofAmerica, 3DivisionofCardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America, 4Division of Cardiac Surgery, Department of Surgery, MassachusettsGeneralHospital,Boston,Massachusetts,UnitedStatesofAmerica Abstract Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality in the United States. Recent studies suggestthatpericardialadiposetissue(PCAT)secretesinflammatoryfactorsthatcontributetothedevelopmentofCVD.To bettercharacterizetheroleofPCATinthepathogenesisofdisease,weperformedalarge-scaleunbiasedanalysisofthe transcriptionaldifferencesbetweenPCATandsubcutaneousadiposetissue,analysing53microarraysacross19individuals. AsitwasunknownwhetherPCAT-secretedfactorsareproducedbyadipocytesorcellsinthesupportingstromalfraction, we also sought to identify differentially expressed genes in isolated pericardial adipocytes vs. isolated subcutaneous adipocytes.Usingmicroarrayanalysis,wefoundthat:1)pericardialadiposetissueandisolatedpericardialadipocytesboth overexpress atherosclerosis-promoting chemokines and 2) pericardial and subcutaneous fat depots, as well as isolated pericardialadipocytesandsubcutaneousadipocytes,expressspecificpatternsofhomeoboxgenes.Incontrast,acoresetof lipid processing genes showed no significant overlap with differentially expressed transcripts. These depot-specific homeobox signatures and transcriptional profiles strongly suggest different functional roles