Patterns in Age-Seroprevalence Consistent with Acquired Immunity against Trypanosoma brucei in Serengeti Lions 英文参考文献.docVIP

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Patterns in Age-Seroprevalence Consistent with Acquired Immunity against Trypanosoma brucei in Serengeti Lions 英文参考文献.doc

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Patterns in Age-Seroprevalence Consistent with Acquired Immunity against Trypanosoma brucei in Serengeti Lions 英文参考文献

PatternsinAge-SeroprevalenceConsistentwith AcquiredImmunityagainstTrypanosomabruceiin SerengetiLions SueWelburn1*,KimPicozzi1,PaulG.Coleman2,CraigPacker3 1CentreforInfectiousDisease,CollegeofMedicineandVeterinaryMedicine,TheUniversityofEdinburgh,Edinburgh,UnitedKingdom,2DepartmentofInfectiousand TropicalDiseases,LondonSchoolofHygieneandTropicalMedicine,London,UnitedKingdom,3DepartmentofEcology,Evolution,andBehavior,UniversityofMinnesota, Minnesota,UnitedStatesofAmerica Abstract Trypanosomes cause disease in humans and livestock throughout sub-Saharan Africa. Although various species show evidence of clinical tolerance to trypanosomes, until now there has been no evidence of acquired immunity to natural infections.WediscoveredadistinctpeakanddecreaseinageprevalenceofT.bruceis.l.infectioninwildAfricanlionsthatis consistent with being driven by an exposure-dependent increase in cross-immunity following infections with the more geneticallydiversespecies,T.congolensesensulatu.Thecausativeagentofhumansleepingsickness,T.bruceirhodesiense, disappears by 6 years of age apparently in response to cross-immunity from other trypanosomes, including the non- pathogenic subspecies, T. brucei brucei. These findings may suggest novel pathways for vaccinations against trypanosomiasisdespitethenotoriouslycomplexantigenicsurfaceproteinsintheseparasites. Citation:WelburnS,PicozziK,ColemanPG,PackerC(2008)PatternsinAge-SeroprevalenceConsistentwithAcquiredImmunityagainstTrypanosomabruceiin SerengetiLions.PLoSNeglTropDis2(12):e347.doi:10.1371/journal.pntd.0000347 Editor:SerapAksoy,YaleUniversitySchoolofMedicine,UnitedStatesofAmerica ReceivedNovember14,2007;AcceptedNovember12,2008;PublishedDecember9,2008 Copyright: ? 2008 Welburn et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:NSF.Thefundershadnoroleinstu