Patterns of Expression of Vaginal T-Cell Activation Markers during Estrogen-Maintained Vaginal Candidiasis 英文参考文献.docVIP

Original article Patterns of Expression of Vaginal T- Cell Activation Markers during Estrogen- Maintained Vaginal Candidiasis Ameera Al-Sadeq, MSc, Mawieh Hamad, PhD, and Khaled Abu-Elteen, PhD the immunosuppressive activity of estrogen was furtherinvestigated by assessing the pattern of expression of cD25, cD28, cD69, and cD152 onvaginalt cells duringestrogen-maintained vaginalcandidiasis. a precipitous and signi?cantdecrease invaginalfungal burdentoward the end of week 3 postinfectionwas concurrentwith asigni?cantincrease invaginallymphocyte numbers. Duringthis period, the percentage of cD3 and cD3 cells increased from 43% and 15% atday 0 to 77% and 40% atday 28 postinfection. compared with 29% cD152 vaginalt cells innaive mice, 70% of vaginalt cells were cD152 atday 28 postinfection. inconclusion, estrogen-maintained vaginal , cD3 cD4 , cD152 , and cD28 vaginalt cells gradually and signi?cantly increased. the percentage of + + + + + cD3 + + cD4 + + + candidiasis results inpostinfectiontime-dependentchanges inthe patternof expressionof cD152, cD28, and othert-cellmarkers, suggestingthatt cells are subjectto mixed suppressionand activationsignals. Key words: CD28, CD152, estrogen, vaginal candidiasis, vaginal T lymphocytes V aginal candidiasis (VC) is now recognized as a ma- jor health problem for women of childbearing age immune responses converge to protect the host against fun- gal infections (reviewed in Romani15). Intact epithelia and en- dothelia, microbial antagonism, and antimicrobial peptides provide the very ?rst line of defense against fungal infections. Additionally, professional phagocytic cells (neutrophils, monocytes, macrophages, and dendritic cells [DCs]) reduce fungal burden by inducing oxidative and non-oxidative kill- ing of fungi and by restricting fungal growth and infectivity. Nonetheless, localized T cell