Patterns of intron sequence evolution in Drosophila are dependent upon length and GC content 英文参考文献.docVIP

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Patterns of intron sequence evolution in Drosophila are dependent upon length and GC content 英文参考文献.doc

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Patterns of intron sequence evolution in Drosophila are dependent upon length and GC content 英文参考文献

Open Access Re rch 2005HaddrilletVoal.lumesea6, Issue 8, Article R67 Patterns of intron sequence evolution in Drosophila are dependent upon length and GC content Penelope R Haddrill*, Brian Charlesworth*, Daniel L Halligan* and Peter Andolfatto? Addresses: *Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, UK. ?Section of Ecology, Behavior and Evolution, Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA. Correspondence: Penelope R Haddrill. E-mail: p.haddrill@ed.ac.uk Published: 27 July 2005 Received: 4 March 2005 Revised: 25 April 2005 Accepted: 29 June 2005 Genome Biology 2005, 6:R67 (doi:10.1186/gb-2005-6-8-r67) The electronic version of this article is the complete one and can be found online at /2005/6/8/R67 ? 2005 Haddrill et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. PatternsimtporsetAvineatalrnsofoaanlintroniyscstriDsoNnofgAsequenceliynistneeervg-osalptvieivncevolutionigfciuconrdrdievelearrtcgiinoennDrosophilascebideteinwrae225belne icintronnotnrostnralfragmentseinnt.th/pand indivitDrosophilaergence and intmelanogasterron divergence/itandand GC citD.ontent.simulansThis sugg/ests that Abstract Background: Introns comprise a large fraction of eukaryotic genomes, yet little is known about their functional significance. Regulatory elements have been mapped to some introns, though these are believed to account for only a small fraction of genome wide intronic DNA. No consistent patterns have emerged from studies that have investigated general levels of evolutionary constraint in introns. Results: We examine the relationship between intron length and levels of evolutionary constraint by analyzing