Perinatal Na+ Overload Programs Raised Renal Proximal Na+ Transport and Enalapril-Sensitive Alterations of Ang II Signaling Pathways during Adulthood 英文参考文献.docVIP

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Perinatal Na+ Overload Programs Raised Renal Proximal Na+ Transport and Enalapril-Sensitive Alterations of Ang II Signaling Pathways during Adulthood 英文参考文献.doc

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PerinatalNaOverloadProgramsRaisedRenalProximalNaTransportandEnalapril-SensitiveAlterationsofAngIISignalingPathwaysduringAdulthood英文参考文献

PerinatalNa+OverloadProgramsRaisedRenalProximal Na TransportandEnalapril-SensitiveAlterationsofAng IISignalingPathwaysduringAdulthood + EdjairV.Cabral1,3,LeucioD.Vieira-Filho1,3,PauloA.Silva2,3,WilliamsS.Nascimento1,ReginaS.Aires1, FabianaS.T.Oliveira1,RicardoLuzardo2,3,AdalbertoVieyra2,3,AnaD.O.Paixa?o1,3 * 1DepartmentofPhysiologyandPharmacology,FederalUniversityofPernambuco,Recife,Brazil,2CarlosChagasFilhoBiophysicsInstitute,FederalUniversityofRiode Janeiro,Brazil,3NationalInstituteofScienceandTechnologyforStructuralBiologyandBioimaging,RiodeJaneiro,Brazil Abstract Background:HighNa+intakeisarealityinnowadaysandisfrequentlyaccompaniedbyrenalandcardiovascularalterations. + + In this study, renal mechanisms underlying perinatal Na overload-programmed alterations in Na transporters and the renin/angiotensinsystem(RAS)wereinvestigated,togetherwitheffectsofshort-termtreatmentwithenalaprilintermsof reprogrammingmolecularalterationsinkidney. Methodology/PrincipalFindings:MaleadultWistarratswereobtainedfromdamsmaintainedthroughoutpregnancyand lactationonastandarddietanddrinkingwater(control)or0.17MNaCl(salinegroup).Enalapril(100mg/l),anangiotensin converting enzyme inhibitor, was administered for three weeks after weaning. Ninety day old offspring from dams that ++ + drank saline presented with proximal tubules exhibiting increased (Na K )ATPase expression and activity. Ouabain- insensitive Na -ATPase activity remained unchanged but its response to angiotensin II (Ang II) was lost. PKC, PKA, renal + thiobarbituricacidreactivesubstances(TBARS),macrophageinfiltrationandcollagendepositionmarkedlyincreased,and AT2receptorexpressiondecreasedwhileAT1expressionwasunaltered.Earlytreatmentwithenalaprilreducedexpression and activity of (Na K )ATPase, partially recovered the response of Na -ATPase to Ang II, and reduced PKC and PKA ++ + activities independently of whether offspring were exposed to high perinatal Na or not. In addition, treatment with + + enalaprilper sereducedAT