Polymorphisms of the TUB Gene Are Associated with Body Composition and Eating Behavior in Middle-Aged Women 英文参考文献.docVIP
- 1、本文档共8页,可阅读全部内容。
- 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
- 5、该文档为VIP文档,如果想要下载,成为VIP会员后,下载免费。
- 6、成为VIP后,下载本文档将扣除1次下载权益。下载后,不支持退款、换文档。如有疑问请联系我们。
- 7、成为VIP后,您将拥有八大权益,权益包括:VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 8、VIP文档为合作方或网友上传,每下载1次, 网站将根据用户上传文档的质量评分、类型等,对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
Polymorphisms of the TUB Gene Are Associated with Body Composition and Eating Behavior in Middle-Aged Women 英文参考文献
PolymorphismsoftheTUBGeneAreAssociatedwith
BodyCompositionandEatingBehaviorinMiddle-Aged
Women
JanaV.vanVliet-Ostaptchouk1,2,N.CharlotteOnland-Moret3,4,RonitShiri-Sverdlov2,PatrickJ.J.vanGorp2,AnneCusters2,PetraH.M.Peeters4,
CiscaWijmenga3,5,MartenH.Hofker1,2,YvonneT.vanderSchouw4*
1DepartmentofPathologyandLaboratoryMedicine,UniversityMedicalCenterGroningen,UniversityofGroningen,Groningen,TheNetherlands,
2DepartmentofMolecularGenetics,MaastrichtUniversity,Maastricht,TheNetherlands,3DBG-DepartmentofMedicalGenetics,UniversityMedical
Center Utrecht, Utrecht, The Netherlands, 4Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The
Netherlands,5DepartmentofGenetics,UniversityMedicalCenterGroningen,UniversityofGroningen,Groningen,TheNetherlands
Background. The TUB gene, encoding an evolutionary conserved protein, is highly expressed in the hypothalamus and
mightactasatranscriptionfactor.MutationsinTUBcauselate-onsetobesity,insulin-resistanceandneurosensorydeficitsin
mice. An association of common variants in the TUB gene with body weight in humans has been reported. Methods/
Findings. The aim was to investigate the relationship of single nucleotide polymorphisms (SNPs) of the TUB gene
(rs2272382, rs2272383 and rs1528133) with both anthropometry and self-reported macronutrient intake from a validated
foodfrequencyquestionnaire.Theseassociationswerestudiedinapopulation-based,cross-sectionalstudyof1680middle-
aged Dutch women, using linear regression analysis. The minor allele C of the rs1528133 SNP was significantly associated
with increased weight (+1.88kg, P=0.022) and BMI (+0.56 units, P=0.05). Compared with non-carriers, both AG
heterozygotes and AA homozygotes of the rs2272382 SNP derived less energy from fat (AG: 20.5560.28%, P=0.05, AA:
20.9560.48%, P=0.047). However, both genotypes were associated with an increased energy intake from carbohydrates
(0.6960.33%, P=0.04 and 1.6860.56%, P=0.003, respectively), mainly b
您可能关注的文档
- Polymorphic Variation in TIRAP Is Not Associated with Susceptibility to Childhood TB but May Determine Susceptibility to TBM in Some Ethnic Groups 英文参考文献.doc
- Polymorphism rs11085226 in the Gene Encoding Polypyrimidine Tract-Binding Protein 1 Negatively Affects Glucose-Stimulated Insulin Secretion 英文参考文献.doc
- Polymorphism in regulatory gene sequences 英文参考文献.doc
- Polymorphism of β-casein in the Creole goat of Guadeloupe evidence for a null allele 英文参考文献.doc
- Polymorphism rs4919510CG in Mature Sequence of Human MicroRNA-608 Contributes to the Risk of HER2-Positive Breast Cancer but Not Other Subtypes 英文参考文献.doc
- Polymorphism of the hereditary rhabdovirus sigma in wild populations of its host, Drosophila melanogaster 英文参考文献.doc
- Polymorphisme des caséines αs1 et αs2 de la chèvre (Capra hircus) 英文参考文献.doc
- Polymorphisme de la caséine αs2 des Bovinés caractérisation du variant C du Yak (Bos grunniens) 英文参考文献.doc
- Polymorphismes biochimiques de la poule domestique. III. – étude des protéines de l'albumen de la souche marans S 33 英文参考文献.doc
- Polymers for DNA Delivery 英文参考文献.doc
最近下载
- 网络空间信息安全(第2版)习题与思考题参考答案.pdf
- 微肿瘤PTC体外药敏检测服务2023年.pdf VIP
- 教科版四年级科学上册第三单元《第1课让小车运动起来》优秀教学设计.docx VIP
- 病例报告表完整版.doc
- 电影售票管理平台.docx
- 统编版语文三年级上册《对话中提示语的位置及标点》课件.pptx VIP
- AQ_ 4272-2016 铝镁制品机械加工粉尘防爆安全技术规范.pdf
- 4第四章-金融市场及其构成(货币金融学(蒋先玲编著)第3版ppt课件可编辑).pptx
- 部编版语文二年级下册 第三单元大单元任务群“发现汉字的秘密”(一等奖创新教学设计).pdf VIP
- 《活着》读书分享.pptx VIP
文档评论(0)