Polymorphisms of the TUB Gene Are Associated with Body Composition and Eating Behavior in Middle-Aged Women 英文参考文献.docVIP

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Polymorphisms of the TUB Gene Are Associated with Body Composition and Eating Behavior in Middle-Aged Women 英文参考文献.doc

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Polymorphisms of the TUB Gene Are Associated with Body Composition and Eating Behavior in Middle-Aged Women 英文参考文献

PolymorphismsoftheTUBGeneAreAssociatedwith BodyCompositionandEatingBehaviorinMiddle-Aged Women JanaV.vanVliet-Ostaptchouk1,2,N.CharlotteOnland-Moret3,4,RonitShiri-Sverdlov2,PatrickJ.J.vanGorp2,AnneCusters2,PetraH.M.Peeters4, CiscaWijmenga3,5,MartenH.Hofker1,2,YvonneT.vanderSchouw4* 1DepartmentofPathologyandLaboratoryMedicine,UniversityMedicalCenterGroningen,UniversityofGroningen,Groningen,TheNetherlands, 2DepartmentofMolecularGenetics,MaastrichtUniversity,Maastricht,TheNetherlands,3DBG-DepartmentofMedicalGenetics,UniversityMedical Center Utrecht, Utrecht, The Netherlands, 4Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands,5DepartmentofGenetics,UniversityMedicalCenterGroningen,UniversityofGroningen,Groningen,TheNetherlands Background. The TUB gene, encoding an evolutionary conserved protein, is highly expressed in the hypothalamus and mightactasatranscriptionfactor.MutationsinTUBcauselate-onsetobesity,insulin-resistanceandneurosensorydeficitsin mice. An association of common variants in the TUB gene with body weight in humans has been reported. Methods/ Findings. The aim was to investigate the relationship of single nucleotide polymorphisms (SNPs) of the TUB gene (rs2272382, rs2272383 and rs1528133) with both anthropometry and self-reported macronutrient intake from a validated foodfrequencyquestionnaire.Theseassociationswerestudiedinapopulation-based,cross-sectionalstudyof1680middle- aged Dutch women, using linear regression analysis. The minor allele C of the rs1528133 SNP was significantly associated with increased weight (+1.88kg, P=0.022) and BMI (+0.56 units, P=0.05). Compared with non-carriers, both AG heterozygotes and AA homozygotes of the rs2272382 SNP derived less energy from fat (AG: 20.5560.28%, P=0.05, AA: 20.9560.48%, P=0.047). However, both genotypes were associated with an increased energy intake from carbohydrates (0.6960.33%, P=0.04 and 1.6860.56%, P=0.003, respectively), mainly b