Polymorphisms, Mutations, and Amplification of the EGFR Gene in Non-Small Cell Lung Cancers 英文参考文献.docVIP
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Polymorphisms, Mutations, and Amplification of the EGFR Gene in Non-Small Cell Lung Cancers 英文参考文献
o
PL SMEDICINE
Polymorphisms,Mutations,andAmplification
oftheEGFRGeneinNon-SmallCell
LungCancers
Masaharu Nomura1,Hisayuki Shigematsu1,Lin Li2,Makoto Suzuki1,Takao Takahashi1,Pila Estess3,Mark Siegelman3,
Ziding Feng2,Harubumi Kato4,Antonio Marchetti5,Jerry W. Shay6,Margaret R.Spitz7,Ignacio I.Wistuba8,
John D.Minna1,9,10,Adi F.Gazdar1,3*
1HamonCenterforTherapeuticOncologyResearch,UniversityofTexasSouthwesternMedicalCenter,Dallas,Texas,UnitedStatesofAmerica,2CancerPreventionResearch,
Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, 3 Department of Pathology, University of Texas
Southwestern Medical Center, Dallas, Texas, United States ofAmerica, 4 First Department of Surgery,Tokyo Medical University, Tokyo, Japan, 5 Pathology Unit, Clinical
ResearchCenter,CenterofExcellenceonAging,UniversityFoundation,Chieti,Italy,6DepartmentofCellBiology,UniversityofTexasSouthwesternMedicalCenter,Dallas,
Texas,UnitedStatesofAmerica,7DepartmentofEpidemiology,UniversityofTexasM.D.AndersonCancerCenter,Houston,Texas,UnitedStatesofAmerica,8Department
of Pathology, University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America, 9 Department of Internal Medicine, University of Texas
Southwestern MedicalCenter, Dallas, Texas, United StatesofAmerica, 10Department ofPharmacology,UniversityofTexasSouthwestern MedicalCenter, Dallas, Texas,
UnitedStatesofAmerica
Funding:Thisresearchwas
supportedbygrantsfromthe
SpecializedProgramofResearch
ExcellenceinLungCancer
ABSTRACT
Background
(P50CA70907)andtheEarly
DetectionResearchNetwork
(5U01CA8497102),NationalCancer
Institute,Bethesda,Maryland.The
fundershadnoroleinstudydesign,
datacollectionandanalysis,decision
topublish,orpreparationofthe
manuscript.
Theepidermalgrowthfactorreceptor(EGFR)geneistheprototypememberofthetypeIreceptor
tyrosinekinase(TK)familyandplaysapivotalroleincellproliferationanddifferentiation.Thereare
three well described polymorphism
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