Population Attributable Risk of Unintentional Childhood Poisoning in Karachi Pakistan 英文参考文献.docVIP
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Population Attributable Risk of Unintentional Childhood Poisoning in Karachi Pakistan 英文参考文献
PopulationAttributableRiskofUnintentionalChildhood
PoisoninginKarachiPakistan
BilalAhmed1*,ZafarFatmi2,AmnaR.Siddiqui2,3
1Department of Medicine, Aga Khan University, Karachi, Pakistan, 2Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan, 3King Saud
University,CollegeofMedicineKingdomofSaudiArabia,Riyadh,SaudiArabia
Abstract
Background:Thepercentageofunintentionalchildhoodpoisoningcasesinagivenpopulationattributabletospecificrisk
factors (i.e., the population attributable risk) which can be calculated; determination of such risk factors associated with
potentiallymodifiableriskfactors,arenecessarytofocusonthepreventionstrategies.
Methods:WecalculatedPARs,using120caseswithunintentionalpoisoningand360controlsinahospitalbasedmatched
case-controlstudy.Theriskfactorswereaccessibilitytohazardouschemicalsandmedicinesduetounsafestorage,child
behaviorreportedashyperactive,storageofkeroseneandpetroleuminsoftdrinkbottles,lowsocioeconomicclass,less
educationofthemotherandthehistoryofpreviouspoisoning.
Results:Thefollowingattributedriskswereobserved:12%(95%confidenceinterval[CI]=8%–16%)forbothchemicalsand
medicinesstoredunsafe,19%(15%–23%)forchildreportedashyperactive,40%(38%–42%)forstorageofkeroseneand
petroleum in soft drink bottles, 48% (42%–54%) for low socioeconomic status, 38% (32%–42%) for no formal mothers
educationand5.8%(2%–10%)forhistoryofpreviouspoisoning.48%ofcasesforoverallstudypopulationwhichcouldbe
attributedtoatleastoneofthesixriskfactors.Amonggirls,thisproportionwas23%and43%amongboys.Abouthalfof
theunintentionalchildhoodpoisoningcasesinthisPakistanipopulationcouldbeavoided.
Conclusion: Exposuretopotentially modifiable risk indicators explained about half of the cases of unintentional poisoning
amongchildrenunderfiveyearsofageinthisPakistanipopulation,indicatingthetheoreticalscopeforpreventionofthedisease.
Citation:AhmedB,FatmiZ,SiddiquiAR(2011)PopulationAttributableRiskofUnintentionalChildhoodPoisoninginKarachiPakistan.PLoSONE6(10
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