Population Based Study of 12 Autoimmune Diseases in Sardinia, Italy Prevalence and Comorbidity 英文参考文献.docVIP
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Population Based Study of 12 Autoimmune Diseases in Sardinia, Italy Prevalence and Comorbidity 英文参考文献
PopulationBasedStudyof12AutoimmuneDiseasesin
Sardinia,Italy:PrevalenceandComorbidity
ClaudiaSardu1*,EleonoraCocco2,AlessandraMereu1,RobertaMassa1,AlessandroCuccu1 ,Maria
GiovannaMarrosu2,PaoloContu1
1DipartimentodiSanita` Pubblica,Universita` diCagliari,Cagliari,Italy,2CentroSclerosiMultipla,DipartimentodiScienzeCardiovascolarieNeurologiche,Universita` di
Cagliari,Cagliari,Italy
Abstract
Background:Thelimitedavailabilityofprevalencedatabasedonarepresentativesampleofthegeneralpopulation,and
thelimitednumberofdiseases consideredinstudiesaboutco-morbidityarethecriticalfactorsinstudyofautoimmune
diseases. This paper describes the prevalence of 12 autoimmune diseases in a representative sample of the general
populationintheSouthofSardinia,Italy,andteststhehypothesisofanoverallassociationamongthesediseases.
Methods:Datawereobtainedfrom21GPs.Thesampleincluded25,885people.Prevalencedatawereexpressedwith95%
Poisson C.I. The hypothesis of an overall association between autoimmune diseases was tested by evaluating the co-
occurrencewithinindividuals.
Results:Prevalenceper100,000are:552rheumatoidarthritis,124ulcerativecolitis,15Crohn’sdisease,464type1diabetes,
81 systemic lupus erythematosus, 124 celiac disease, 35 myasthenia gravis, 939 psoriasis/psoriatic arthritis, 35 systemic
sclerosis,224multiplesclerosis,31Sjogren’ssyndrome,and2,619autoimmunethyroiditis.Anoverallassociationbetween
autoimmunedisorderswashighlighted.
Conclusions:Thecomparisonswithprevalencereportedincurrentliteraturedonotshowoutliervalues,exceptpossiblyfor
a few diseases like celiac disease and myasthenia gravis. People already affected by a first autoimmune disease have a
higherprobabilityofbeingaffectedbyasecondautoimmunedisorder.Inthepresentstudy,thesamplesize,togetherwith
thelowoverallprevalenceofautoimmunediseasesinthepopulation,didnotallowustoexaminewhichdiseasesaremost
frequently associated with other autoimmune diseases. However, this paper makes available an adequate control
populationf
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