Population Genetic Structure and Origins of Native Hawaiians in the Multiethnic Cohort Study 英文参考文献.docVIP
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Population Genetic Structure and Origins of Native Hawaiians in the Multiethnic Cohort Study 英文参考文献
PopulationGeneticStructureandOriginsofNative
HawaiiansintheMultiethnicCohortStudy
SungK.Kim1,2,ChristopherR.Gignoux1,JeffreyD.Wall1,AnnetteLum-Jones3,HansongWang3,
ChristopherA.Haiman4,GaryK.Chen4,BrianE.Henderson4,LaurenceN.Kolonel3,LoicLeMarchand3,
DanielO.Stram4,RichaSaxena5,6,IonaCheng3*
1InstituteforHumanGenetics,UniversityofCaliforniaSanFrancisco,SanFrancisco,California,UnitedStatesofAmerica,2Sequenom,Incorporated,SanDiego,California,
UnitedStatesofAmerica,3EpidemiologyProgram,UniversityofHawai’iCancerCenter,Honolulu,Hawaii,UnitedStatesofAmerica,4DepartmentofPreventiveMedicine,
NorrisComprehensiveCancerCenter,KeckSchoolofMedicine,UniversityofSouthernCalifornia,LosAngeles,California,UnitedStatesofAmerica,5PrograminMedical
andPopulationGenetics,BroadInstitute,Cambridge,Massachusetts,UnitedStatesofAmerica,6CenterforHumanGeneticsResearch,MassachusettsGeneralHospital,
Boston,Massachusetts,UnitedStatesofAmerica
Abstract
ThepopulationgeneticstructureofNativeHawaiianshasyettobecomprehensivelystudied,andtheancestraloriginsof
Polynesians remain in question. In this study, we utilized high-resolution genome-wide SNP data and mitochondrial
genomes of 148 and 160 Native Hawaiians, respectively, to characterize their population structure of the nuclear and
mitochondrial genomes, ancestral origins, and population expansion. Native Hawaiians, who self-reported full Native
Hawaiianheritage,demonstrated78%NativeHawaiian,11.5%European,and7.8%Asianancestrywith99%belongingto
theB4mitochondrialhaplogroup.TheestimatedproportionsofNativeHawaiianancestryforthosewhoreportedmixed
ancestry (i.e. 75% and 50% Native Hawaiian heritage) were found to be consistent with their self-reported heritage. A
significant proportion of Melanesian ancestry (mean=32%) was estimated in 100% self-reported Native Hawaiians in an
ADMIXTURE analysis of Asian, Melanesian, and Native Hawaiian populations of K=2, where K denotes the number of
ancestralpopulations.ThisnotableproportionofMelanesianadmixturesupp
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