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Poor Prognosis of Gastric Adenocarcinoma with Decreased Expression of AHRR 英文参考文献
PoorPrognosisofGastricAdenocarcinomawith
DecreasedExpressionofAHRR
Yuan-fangLi1,2.,Dan-danWang1.,Bai-weiZhao1,2.,WeiWang1,2,Shu-qiangYuan1,2,Chun-yuHuang1,2
,
Yong-mingChen1,2,YanZheng1,2,RajivPrasadKeshari1,2,Jian-chuanXia1*,Zhi-weiZhou1,2*
1StateKeyLaboratoryofOncologyinSouthChinaandDepartmentofExperimentalResearch,SunYat-senUniversityCancerCenter,Guangzhou,People’sRepublicof
China,2DepartmentofGastricandPancreaticSurgery,SunYat-senUniversityCancerCenter,Guangzhou,People’sRepublicofChina
Abstract
Background: The aryl hydrocarbon receptor (AHR) repressor (AHRR), a member of growing superfamily, is a basic-helix-
loop-helix/Per-AHRnucleartranslocator(ARNT)-Sim(bHLH-PAS)protein.Recently,AHRRhasbeenproposedtofunctionasa
putativenewtumorsuppressorgenebasedonsomerelevantstudiesinmultipletypesofhumancancers.Thiscurrentstudy
aimstoinvestigateAHHRexpressionanditsprognosticsignificanceinprimarygastricadenocarcinoma.
Methodology/PrincipalFindings:TheexpressionlevelofAHRRwasanalyzedusingreal-timequantitativePCR(RT-qPCR),
westernblotting,andimmunohistochemicalstaining.ItwasclearlyshowedthattheexpressionstatusofAHRRwasreduced
intumortissuesamplescomparedwiththatinmatchedadjacentnon-tumortissuesamplesbyRT-qPCR(P=0.0423)and
western blotting analysis (P=0.004). Moreover, data revealed that AHRR without exon 8 (the active isoform) was the
predominantformeitherintumortissues(66.7%,8/12)orinmatchedadjacentnon-tumortissues(100.0%,12/12),andthe
mRNAlevelofthisisoformwassignificantlyreducedintumortissues(P=0.006).Immunohistochemistryanalysisindicated
thatAHRRexpressionwassignificantlydecreasedin175of410(42.7%)gastricadenocarcinomacases.Kaplan-Meiersurvival
curves and Multivariate Cox analysis revealed that decreased expression of AHRR was significantly associated with poor
prognosisingastricadenocarcinomapatients.
Conclusions/Significance:Ourdatasuggeststhat,inprimarygastricadenocarcinoma,AHRRmayplayasasuppressorgene
anditsexpressionstatushasthepotentialtobeanindependentprognosticfact
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