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Porin new light onto chromatin and nuclear organization 英文参考文献
Minireview
Porin new light onto chromatin and nuclear organization
Lee E Finlan and Wendy A Bickmore
Address: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh,
EH4 2XU, UK.
Correspondence: Lee E Finlan. Email: lfinlan@hgu.mrc.ac.uk; Wendy A Bickmore Email. w.bickmore@hgu.mrc.ac.uk
Published: 16 May 2008
Genome Biology 2008, 9:222 (doi:10.1186/gb-2008-9-5-222)
The electronic version of this article is the complete one and can be
found online at /2008/9/5/222
? 2008 BioMed Central Ltd
Abstract
A recent report identifies sites in the human genome that can associate with nucleoporin 93, a
subunit of the nuclear pore complex. These associations are modulated by levels of global histone
acetylation and highlight the dynamic nature of chromatin organization in the nucleus.
Nuclear pore complexes (NPCs) in the nuclear envelope
mediate the selective exchange of macromolecules into and
out of the nucleus by facilitated diffusion. The NPC is com-
posed of multiple copies of roughly 30 distinct nucleoporins
[1-3] and its structure is conserved throughout eukaryotes.
Although numerous studies have examined how nucleoporins
function in nucleo-cytoplasmic transport, relatively little
attention has been paid to any role they might have in
influencing genome organization in mammalian cells.
nucleoplasmic protein [12]. The Silver lab had previously
shown by ChIP that various components of the yeast NPC,
including Nic96, the yeast homolog of NUP93, could asso-
ciate with specific regions of the yeast genome [13]. They
have now extended this approach to regions of three
different human chromosomes that interact with NUP93 in
HeLa cells [10]. After cell fixation with dimethyl adipimidate
and paraformaldehyde, lysis in detergent and then sonica-
tion, DNA sequences associating with NUP93 in the soluble
extr
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