Post-Pandemic Seroprevalence of Pandemic Influenza A (H1N1) 2009 Infection (Swine Flu) among Children 18 Years in Germany 英文参考文献.docVIP
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Post-Pandemic Seroprevalence of Pandemic Influenza A (H1N1) 2009 Infection (Swine Flu) among Children 18 Years in Germany 英文参考文献
Post-PandemicSeroprevalenceofPandemicInfluenzaA
(H1N1)2009Infection(SwineFlu)amongChildren,18
YearsinGermany
Ru¨digervonKries1.,SusanneWeiss1.,GerhardFalkenhorst2,StephanWirth3,PetraKaiser4 ,Hans-Iko
Huppertz4,TobiasTenenbaum5,HorstSchroten5,AndreaStreng6,JohannesLiese6,SonuShai7 ,Tim
Niehues7,HermannGirschick8,EllenKuscher9,AxelSauerbrey9,JochenPeters10,CarlHeinzWirsingvon
Ko¨nig11,SimonRu¨ckinger1,WalterHampl12,DetlefMichel12,ThomasMertens1,2*
1Institut fu¨r Soziale Pa¨diatrie und Jugendmedizin, Ludwig-Maximilians-Universita¨t, Mu¨nchen, Germany, 2Abteilung fu¨r Infektionsepidemiologie, Robert Koch-Institut,
Berlin,Germany,3Zentrumfu¨rKinder-undJugendmedizin,HeliosKlinikum-Universita¨t Witten/Herdecke,Wuppertal,Germany,4Professor-Hess-Kinderklinik,Klinikum
Bremen-Mitte, Bremen, Germany, 5Universita¨tskinderklinik, Universita¨t Heidelberg, Mannheim, Germany, 6Universita¨tskinderklinik, Wu¨rzburg, Germany, 7Helios
Klinikum,Krefeld,Germany,8Klinikfu¨rKinder-undJugendmedizin,VivantesKlinikumimFriedrichshain,Berlin,Germany,9HeliosKlinikum,Erfurt,Germany,10Abteilung
fu¨rKinder-undJugendmedizin,KlinikumDritterOrden,Mu¨nchen-Nymphenburg,Germany,11Institutfu¨rHygieneundLaboratoriumsmedizin,HeliosKlinikum,Krefeld,
Germany,12Institutfu¨rVirologie,Universita¨tsklinikum, Ulm,Germany
Abstract
Background:WedeterminedantibodiestothepandemicinfluenzaA(H1N1)2009virusinchildrentoassess:theincidence
of (H1N1) 2009 infections in the 2009/2010 season in Germany, the proportion of subclinical infections and to compare
titersinvaccinatedandinfectedchildren.
Methodology/Principal Findings: Eight pediatric hospitals distributed over Germany prospectively provided sera from
in-oroutpatientsaged1to17yearsfromApril1sttoJuly31st2010.Vaccinationhistory,recallofinfectionsandsociodemo-
graphicfactorswereascertained.Antibodytitersweremeasuredwithasensitiveandspecificin-househemagglutination
inhibitiontest(HIT)andcomparedtoage-matchedseracollectedduring6monthsbeforetheonsetofthepandemicin
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