Preoperative prediction of pediatric patients with effusions and edema following cardiopulmonary bypass surgery by serological and routine laboratory data 英文参考文献.docVIP
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Preoperative prediction of pediatric patients with effusions and edema following cardiopulmonary bypass surgery by serological and routine laboratory data 英文参考文献
Critical Care June 2002 Vol 6 No 3 Bocsi et al.
Research
Preoperative prediction of pediatric patients with effusions and
edema following cardiopulmonary bypass surgery by serological
and routine laboratory data
József Bocsi1, J?rg Hambsch2, Pavel Osmancik3, Peter Schneider4, Günter Valet5 and Attila Tárnok6
1Director, Flow Cytometry Unit, 1st Department of Pathology, Semmelweis University, Budapest, Hungary
2Assistant Medical Director, Pediatric Cardiology, Heart Center Leipzig GmbH, University of Leipzig, Germany
3Assistant Cardiologist, Cardiac Center, University Hospital Kralovske Vinohrady, Charles University, Prague, Czech Republic
4Director, Pediatric Cardiology, Heart Center Leipzig GmbH, University of Leipzig, Germany
5Head, Cell Biochemistry Group, Max-Planck-Institute for Biochemistry, Martinsried, Munich, Germany
6Head, Research Facility, Pediatric Cardiology, Heart Center Leipzig GmbH, University of Leipzig, Germany
Correspondence: Attila Tárnok, tarnok@medizin.uni-leipzig.de
Received: 19 February 2002
Accepted: 22 February 2002
Published: 8 April 2002
Critical Care 2002, 6:226-233
? 2002 Bocsi et al., licensee BioMed Central Ltd
(Print ISSN 1364-8535; Online ISSN 1466-609X)
Abstract
Aim: Postoperative effusions and edema and capillary leak syndrome in children after cardiac surgery
with cardiopulmonary bypass constitute considerable clinical problems. Overshooting immune
response is held to be the cause. In a prospective study we investigated whether preoperative immune
status differences exist in patients at risk for postsurgical effusions and edema, and to what extent
these differences permit prediction of the postoperative outcome.
Methods: One-day preoperative serum levels of immunoglobulins, complement, cytokines and
chemokines, soluble adhesion molecules and receptors as well as clinical chemistry parameters such
as differential counts, creatinine, blood coagulation status (altogether 56 parameters) we
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