Presence of p24-Antigen Associated to Erythrocyte in HIV-Positive Individuals Even in Patients with Undetectable Plasma Viral Load 英文参考文献.docVIP

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Presence of p24-Antigen Associated to Erythrocyte in HIV-Positive Individuals Even in Patients with Undetectable Plasma Viral Load 英文参考文献.doc

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Presence of p24-Antigen Associated to Erythrocyte in HIV-Positive Individuals Even in Patients with Undetectable Plasma Viral Load 英文参考文献

Presenceofp24-AntigenAssociatedtoErythrocytein HIV-PositiveIndividualsEveninPatientswith UndetectablePlasmaViralLoad MariaNoe′ Garcia*,MariaSoldosRamosFarias,MariaMercedesAvila,′ RobertoDanielRabinovich MicrobiologyDepartment,SchoolofMedicine,NationalReferenceCenterforAIDS,UniversityofBuenosAires,BuenosAires,Argentina Abstract Background:HIVadherencetoerythrocyteshasbeendemonstratedinvitro,andithasbeensuggestedthaterythrocytes may be carriers of the virus. However, the association between HIV particles or viral proteins and erythrocytes in HIV- infectedindividualsisstilltobeelucidated. Methodology/PrincipalFindings:HIV-positiveparticipants(n=112)wereclassifiedintotwogroupsaccordingtovaluesof three plasma viral loads (pVL) determined during the 12-month period prior to the study. The first group included 71 individuals with detectable pVL, whereas the second group included 41 individuals with undetectable pVL. Plasma viral load,erythrocyte-associatedp24-antigenandp24-antigeninplasmaweredeterminedatthemomentofthestudy.Atotal of51outofthe71patientswithdetectablepVLshowederythrocyte-associatedp24-antigenwhereas13showedp24-anti- geninplasma.Twenty-twooutofthe51patientswitherythrocyte-associatedp24-antigenshowedpVL,10,000copies/ml andundetectablep24-antigeninplasma.Thedataindicatesthattheamountoferythrocyte-associatedp24-antigenwasnot related top24-antigen in plasma or pVL levels in this group. Among the 41 patients with prior undetectable pVL, eight presented detectable pVL and erythrocyte-associated p24-antigen at the moment of the study. The other 33 showed undetectable pVL and five of these presented erythrocyte-associated p24-antigen. A positive relationship was found between the presence of erythrocyte-associated p24-antigen and the detectable pVL at the moment of the study (p,0.00001).Evenmore,inanotherseriesofassays,adetectableviralloadassociatedtoerythrocyteswasdeterminedandit wasalwaysaccompaniedbyerythrocyte-associatedp24-antigendetection. Conclusions