Preparation of Benzalkonium Salts Differing in the Length of a Side Alkyl Chain 英文参考文献.docVIP

Molecules 2007, 12, 2341-2347 molecules ISSN 1420-3049 ? 2007 by MDPI /molecules Communication Preparation of Benzalkonium Salts Differing in the Length of a Side Alkyl Chain Kamil Kuca 1,2,3, Jan Marek 4,5, Petr Stodulka 1, Kamil Musilek 2,5,*, Petra Hanusova 4, Martina Hrabinova 1 and Daniel Jun 1,2 1 Center of Advanced Studies, Faculty of Military Health Sciences, Hradec Kralove, Czech Republic 2 Department of Toxicology, Faculty of Military Health Sciences, Hradec Kralove, Czech Republic 3 Department of Chemistry, Faculty of Sciences, J.E. Purkinje University, Usti nad Labem, Czech Republic 4 Vakos XT, Prague, Czech Republic 5 Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Hradec Kralove, Czech Republic * Author to whom correspondence should be addressed; E-mail: musilek@pmfhk.cz Received: 3 September 2007; in revised form 3 October 2007 / Accepted: 4 October 2007 / Published: 24 October 2007 Abstract: Benzalkonium salts are widely used as disinfectants, biocides and detergents, among a variety of other applications. The cationic surface-activity of these salts determines their potential to act as a biocide on both target and non-target organisms. In this study, a quick synthesis of a complete set of the benzalkonium salts differing in the length of an alkylating chain (from C2 to C20) is described. Moreover, their 1H-NMR, HPLC-MS, TLC and HPLC analysis were recorded. Keywords: Benzalkonium salt, detergent, surfactant, biocide, HPLC, TLC. Introduction Quaternary compounds, including the benzalkonium salts, constitute an economically important class of industrial chemicals that are widely distributed among a diverse array of products and users  Molecules 2007, 12 2342 from an industrial to the household sector. Because of their strong cationic surface activity, quaternary compounds are used primarily as disinfectants, biocides, and detergents, but