Preparation of Candesartan and Atorvastatin Nanoparticles by Solvent Evaporation 英文参考文献.docVIP

Molecules 2012, 17, 13221-13234; doi:10.3390/molecules171113221 OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Preparation of Candesartan and Atorvastatin Nanoparticles by Solvent Evaporation ? Eliska Vaculikova 1,2,*, Veronika Grunwaldova 3,4, Vladimir Kral 3, Jiri Dohnal 1,5 and Josef Jampilek 1,5, * 1 Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackeho 1/3, 612 42 Brno, Czech Republic 2 3 Nanotechnology Centre, VSB—Technical University of Ostrava, 17. listopadu 15/2172, 708 33 Ostrava, Czech Republic Institute of Chemical Technology, Faculty of Chemical Engineering, Technicka 5, 166 28 Prague 6, Czech Republic 4 5 Institute of Inorganic Chemistry, Academy of Science, 250 68 Rez, Czech Republic Research Institute for Pharmacy and Biochemistry, Lidicka 1879/48, 602 00 Brno, Czech Republic ? Preliminary results were presented at The Sixteenth Electronic Conference on Synthetic Organic Chemistry (ECSOC-16, /presentation/1008), 1–30 November, 2012 (paper B1008). * Authors to whom correspondence should be addressed; E-Mails: eliskavaculikova@seznam.cz (E.V.); josef.jampilek@ (J.J.); Tel.: +420-541-562-925 (J.J.); Fax: +420-541-240-607 (J.J.). Received: 8 October 2012; in revised form: 31 October 2012 / Accepted: 2 November 2012 / Published: 6 November 2012 Abstract: The solubility, absorption and distribution of a drug are involved in the basic aspects of oral bioavailability Solubility is an essential characteristic and influences the efficiency of the drug. Over the last ten years, the number of poorly soluble drugs has steadily increased. One of the progressive ways for increasing oral bioavaibility is the technique of nanoparticle preparation, which allows many drugs to thus reach the intended site of action. Candesartan cilexetil and atorvastatin, belonging to class II of the biopharmaceutical classification system, were chosen as model active