Prevalence and Risk Factors of Lassa Seropositivity in Inhabitants of the Forest Region of Guinea A Cross-Sectional Study 英文参考文献.docVIP

PrevalenceandRiskFactorsofLassaSeropositivityin InhabitantsoftheForestRegionofGuinea:A Cross-SectionalStudy SolenKerne′is1*,LamineKoivogui2,N’FalyMagassouba2,KekouraKoulemou2,RosamundLewis1, AristideAplogan1,RebeccaF.Grais1,PhilippeJ.Guerin1,ElisabethFichet-Calvet3 1Epicentre,Paris,France,2SurveillanceandResearchProjectonViralHemorrhagicFevers(Lassa,EbolaandYellowFever)inWestAfrica,Conakry,Guinea,3Evolutionary Biologygroup,UniversityofAntwerp,Antwerp,Belgium Abstract Background: Lassa fever is a viral hemorrhagic fever endemic in West Africa. The reservoir host of the virus is a multimammate rat, Mastomys natalensis. Prevalence estimates of Lassa virus antibodies in humans vary greatly between studies,andthemainmodesoftransmissionofthevirusfromrodentstohumansremainunclear.Weaimedto(i)estimate theprevalenceofLassavirus–specificIgGantibodies(LVIgG)inthehumanpopulationofaruralareaofGuinea,and(ii) identifyriskfactorsforpositiveLVIgG. MethodsandFindings:Apopulation-basedcross-sectionalstudydesignwasused.InApril2000,allindividualsoneyearof age and older living in three prefectures located in the tropical secondary forest area of Guinea (Gueckedou, Lola and Yomou)weresampledusingtwo-stageclustersampling.Foreachindividualidentifiedbythesamplingprocedureandwho agreedtoparticipate,astandardizedquestionnairewascompletedtocollectdataonpersonalexposuretopotentialrisk factorsforLassafever(mainlycontactwithrodents),andabloodsamplewastestedforLVIgG.Amultiplelogisticregression modelwasusedtodetermineriskfactorsforpositiveLVIgG.Atotalof1424subjectswereinterviewedand977serawere tested. Prevalence of positive LV Ig was of 12.9% [10.8%–15.0%] and 10.0% [8.1%–11.9%] in rural and urban areas, respectively.TworiskfactorsofpositiveLVIgGwereidentified:tohave,inthepasttwelvemonths,undergoneaninjection (oddsratio[OR]=1.8[1.1–3.1]),orlivedwithsomeonedisplayingahaemorrhage(OR=1.7[1.1–2.9]).Nofactorsrelatedto contactswithratsand/ormiceremainedstatisticallysignificantinthemultivariateanalysis. C