Preserving some sanity 英文参考文献.docVIP

Petsko Genome Biology 2011,12:102 /2011/12/1/102 COMMENT Preserving some sanity Gregory A Petsko* A popular de?nition of insanity - frequently misattributed to Albert Einstein or Benjamin Franklin, but probably originating with novelist Rita Mae Brown in 1983 - is that insanity is doing the same thing over and over again but expecting a di?erent outcome. If that de?nition is a good one, then I think there is a possibility that some of the people who run American science might want to start getting ?tted for a new jacket - the kind where the sleeves wrap around the front and are tied together in back. charged with coordinating the National Cancer Program - in other words, the War on Cancer goes on. Now, certainly there have been many victories in that war: testicular cancer is no longer a fatal disease thanks to Barnett Rosenberg’s discovery of cisplatinum as an anticancer agent; chronic myelogenous leukemia is now treatable by Gleevec and other Bcr-Abl kinase inhibitors thanks to the discovery by David Baltimore and others that survival of that tumor depends on that kinase and the e?orts of Brian Before I explain why I think that could happen, it’s Drucker and Nick Lydon to exploit that discovery; Her-2 worthwhile going over some of the history of scienti?c funding in the United States in the past 40 years, to see how we got ourselves into the situation we’re in now. In positive breast cancer is treatable by antibodies directed at that cell surface protein thanks to the work of Dennis Slamon; other forms of breast cancer can now be attacked 1971, the US President, Richard Nixon announced a by aromatase inhibitors thanks to the work of Angela War on Cancer. In his State of the Union address in Hartley Brodie; multiple myeloma now has a treatment January of that year, he proclaimed: “I will also ask for thanks to the work o