Prevalence of Plasmid-Mediated Quinolone Resistance and Aminoglycoside Resistance Determinants among Carbapeneme Non-Susceptible Enterobacter cloacae 英文参考文献.docVIP

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Prevalence of Plasmid-Mediated Quinolone Resistance and Aminoglycoside Resistance Determinants among Carbapeneme Non-Susceptible Enterobacter cloacae 英文参考文献.doc

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Prevalence of Plasmid-Mediated Quinolone Resistance and Aminoglycoside Resistance Determinants among Carbapeneme Non-Susceptible Enterobacter cloacae 英文参考文献

PrevalenceofPlasmid-MediatedQuinoloneResistance andAminoglycosideResistanceDeterminantsamong CarbapenemeNon-SusceptibleEnterobactercloacae ShifengHuang.,WeiDai.,ShanSun,XiaojiaoZhang,LipingZhang* DepartmentofLaboratoryMedicine,theFirstAffiliatedHospitalofChongqingMedicalUniversity,Chongqing,China Abstract Background: Simultaneous resistance to aminoglycosides and fluoroquinolones in carbapeneme non-susceptible (CNS) isolateswillinevitablycreateproblems.Thepresentstudywasperformedtocharacterizetheprevalenceoftheplasmid- mediatedquinoloneresistance determinants(QRDs)andaminoglycoside resistance determinants(ARDs) amongtheCNS Enterobacter cloacae (E. cloacae) isolates in a Chinese teaching hospital, and to acquire their molecular epidemiological characteristics. Methods:Theb-lactamasesgenes(includingclassAcarbapenemasegenesblaKPC andblaSME,metallo-b-lactamasegenes (MBLs)blaIMP,blaVIMandblaNDM,andextendedspectrumb-lactamases(ESBLs),blaCTX-M,blaTEMandblaSHV),QRDs(including qnrA,qnrB,qnrSandaac(69)-Ib-cr)andARDs(includingaac(69)-Ib,armAandrmtB)ofthese35isolatesweredeterminedby PCRandsequencedbidirectionally.Theclonalrelatednesswasinvestigatedbypulsed-fieldgelelectrophoresis(PFGE). Results: Of the 35 isolates, 9 (25.7%) harbored a carbapenemase gene; 23 (65.7%) carried ESBLs; 24 (68.6%) were QRD positive;and27(77.1%)wereARDpositive.Amongthe5blaIMP-8 positivestrains,4(80%)containedbothESBLandQRD genes,andallthe5(100%)harboredARDgenes.Ofthe23ESBLspositiveisolates,6(26.1%)werecarbapenemasepositive, 14(60.9%)wereQRDpositive,and18(78.3%)wereARDpositive.PFGErevealedgeneticdiversityamongthe35isolates, indicatingthatthehighprevalenceofCNSE.cloacaeisolateswasnotcausedbyclonaldissemination. Conclusion:QRDandARDgeneswerehighlyprevalentamongtheCNSE.cloacaeisolates.Multipleresistantgeneswereco- expressed in the same isolates. The CNS E. cloacae isolate co-expressing blaNDM-1, blaIMP-26, qnrA1 and qnrS1 was first reported. Citation:HuangS,DaiW,SunS,ZhangX,ZhangL(2012)Preva