Primary resistance to clarithromycin, metronidazole and amoxicillin of Helicobacter pylori isolated from Tunisian patients with peptic ulcers and gastritis a prospective multicentre study 英文参考文献.docVIP

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Primary resistance to clarithromycin, metronidazole and amoxicillin of Helicobacter pylori isolated from Tunisian patients with peptic ulcers and gastritis a prospective multicentre study 英文参考文献.doc

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Primary resistance to clarithromycin, metronidazole and amoxicillin of Helicobacter pylori isolated from Tunisian patients with peptic ulcers and gastritis a prospective multicentre study 英文参考文献

BenMansouretal.AnnalsofClinicalMicrobiologyandAntimicrobials2010,9:22 /content/9/1/22 REVIEW OpenAccess Primaryresistancetoclarithromycin,metronidazole andamoxicillinofHelicobacterpyloriisolatedfrom Tunisianpatientswithpepticulcersandgastritis: aprospectivemulticentrestudy KhansaBenMansour1*,ChristopheBurucoa2,MeriemZribi1,AfefMasmoudi1,SamiKaroui3,LamiaKallel3, SoufièneChouaib4,SamiraMatri3,MoniaFekih3,SoniaZarrouk5,MounirLabbene5,JalelBoubaker3,ImedCheikh4, MongiBenHriz6,NadiaSiala6,AbdelkarimAyadi7,AzzaFilali3,NabilBenMami4,TaoufikNajjar8,AhmedMaherzi6, MohamedTaharSfar7,ChedliaFendri1 Abstract Background:ThefrequencyofprimaryresistancetoantibioticsinH.pyloriisolatesisincreasingworldwide.In Tunisia,therearelimiteddataregardingthepatternofH.pyloriantibioticprimaryresistance. Aim:ToevaluatetheprimaryresistanceofH.pyloritoclarithromycin,metronidazoleandamoxicillinandtodetect themutationsinvolvedinclarithromycinresistance. Materialsandmethods:273strainsisolatedfromadultsandchildrenwereenrolled.Theprimaryresistanceto clarithromycin,metronidazoleandamoxicillinwasevaluatedbymeansofE-testminimalinhibitoryconcentration (MIC).Thereal-timePCRusingScorpionprimerswasperformedinallcasestoassessclarithromycinprimary resistanceandpointmutationsinvolved. Results:Noresistancetoamoxicillinwasdetected.Foradults,resistancetoclarithromycinandmetronidazolewas foundrespectivelyin14.6%and56.8%,andrespectivelyin18.8%and25%inchildren.Overall,theratesofglobal primaryresistancetoclarithromycinandmetronidazoleinTunisiawererespectivelydeterminedin15.4%and51.3%. BytheuseofScorpionPCR,theA2143Gwasthemostfrequentpointmutationobserved(88.1%),followedbythe A2142G(11.9%);theA2142Cwasnotfoundand18of42patients(42.8%)wereinfectedbyboththeresistantand thesusceptiblegenotype. Theassociationofclarithromycinresistancewithgenderwasnotstatisticallysignificant,butmetronidazoleresistant strainswereisolatedmorefrequentlyinfemales(67.8%)thaninmales(32.2%)andthedifferencewassignificant. Asforgastroduodenaldisea