Prevention and Treatment of Influenza with Hyperimmune Bovine Colostrum Antibody 英文参考文献.docVIP

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Prevention and Treatment of Influenza with Hyperimmune Bovine Colostrum Antibody 英文参考文献.doc

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Prevention and Treatment of Influenza with Hyperimmune Bovine Colostrum Antibody 英文参考文献

PreventionandTreatmentofInfluenzawith HyperimmuneBovineColostrumAntibody WyChingNg1,VictorWong2,BrianMuller2,GrantRawlin2,LorenaE.Brown1* 1DepartmentofMicrobiologyandImmunology,TheUniversityofMelbourne,Parkville,Victoria,Australia,2ImmuronLimited,NorthMelbourne,Victoria,Australia Abstract Background:Despitetheavailabilityofspecificvaccinesandantiviraldrugs,influenzacontinuestoimposeaheavytollon humanhealthworldwide.Passivetransferofspecificantibody(Ab)mayprovideausefulmeansofpreventingortreating diseasein unvaccinated individualsorthosefailing toadequately seroconvert, especially nowthat resistance toantiviral drugs is on the rise. However, preparation of appropriate Ab in large scale, quickly and on a yearly basis is viewed as a significantlogisticalhurdleforthisapproachtocontrolseasonalinfluenza. Methodology/PrincipalFindings:Inthisstudy,bovinecolostrum,whichcontainsapproximately500gofIgGpermilking peranimal,hasbeeninvestigatedasasourceofpolyclonalantibodyfordeliverytotherespiratorytract.IgGandF(ab’)2 werepurifiedfromthehyperimmunecolostrumofcowsvaccinatedwithinfluenzaA/PuertoRico/8/34(PR8)vaccineand wereshowntohavehighhemagglutination-inhibitoryandvirus-neutralizingtiters.InBALB/cmice,asingleadministration ofeitherIgGorF(ab’)2couldpreventtheestablishmentofinfectionwithasublethaldoseofPR8viruswhengivenasearly as7dayspriortoexposuretovirus.Pre-treatedmicealsosurvivedanotherwiselethaldoseofvirus,theIgG-butnotthe F(ab’)2-treatedmiceshowingnoweightloss.Successfulreductionofestablishedinfectionwiththishighlyvirulentviruswas alsoobservedwithasingletreatment24hraftervirusexposure. Conclusions/Significance: These data suggest that a novel and commercially-scalable technique for preparing Ab from hyperimmunebovinecolostrumcouldallowproductionofavaluablesubstituteforantiviraldrugstocontrolinfluenzawith theadvantageofeliminatingtheneedfordailyadministration. Citation:NgWC,WongV,MullerB,RawlinG,BrownLE(2010)PreventionandTreatmentofInfluenzawithHyperimmune BovineC