Prevention of Disuse Muscle Atrophy by Dietary Ingestion of 8-Prenylnaringenin in Denervated Mice 英文参考文献.docVIP

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Prevention of Disuse Muscle Atrophy by Dietary Ingestion of 8-Prenylnaringenin in Denervated Mice 英文参考文献.doc

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Prevention of Disuse Muscle Atrophy by Dietary Ingestion of 8-Prenylnaringenin in Denervated Mice 英文参考文献

PreventionofDisuseMuscleAtrophybyDietary Ingestionof8-PrenylnaringenininDenervatedMice RieMukai1,HitomiHorikawa1,YutakaFujikura1,TomoyukiKawamura2,HisaoNemoto2, TakeshiNikawa3,JunjiTerao1* 1DepartmentofFoodScience,InstituteofHealthBiosciences,UniversityofTokushimaGraduateSchool,Tokushima,Japan,2DepartmentofPharmaceuticalChemistry, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan, 3Department of Nutritional Physiology, Institute of Health Biosciences, UniversityofTokushimaGraduateSchool,Tokushima,Japan Abstract Flavonoidshaveattractedconsiderableattentioninrelationtotheireffectsuponhealth.8-Prenylnaringenin(8-PN)isfound in the common hop (Humulus lupulus) and assumed to be responsible for the health impact of beer consumption. We wantedtoclarifytheeffectsofprenylationonthephysiologicalfunctionsofdietaryflavonoidsbycomparingtheeffectsof 8-PN with that of intact naringenin in the prevention of disuse muscle atrophy using a model of denervation in mice. Consumptionof8-PN(butnotnaringenin)preventedlossofweightinthegastrocnemiusmusclefurthersupportedbythe lackofinductionoftheproteincontentofakeyubiquitinligaseinvolvedinmuscleatrophy,atrogin-1,andbytheactivation ofAktphosphorylation.8-PNcontentinthegastrocnemiusmusclewastenfoldhigherthanthatofnaringenin.Theseresults suggestedthat,comparedwithnaringenin,8-PNwaseffectivelyconcentratedintoskeletalmuscletoexertitspreventive effects upon disuse muscle atrophy. It is likely that prenylation generates novel functions for 8-PN by enhancing its accumulationintomuscletissuethroughdietaryintake. Citation:MukaiR,HorikawaH,FujikuraY,KawamuraT,NemotoH,etal.(2012)PreventionofDisuseMuscleAtrophybyDietaryIngestionof8-Prenylnaringenin inDenervatedMice.PLoSONE7(9):e45048.doi:10.1371/journal.pone.0045048 Editor:MaurizioD’Incalci,IstitutodiRicercheFarmacologicheMarioNegri,Italy ReceivedMay15,2012;AcceptedAugust15,2012;PublishedSeptember19,2012 Copyright: ? 2012 Mukai et al. This is an open-access art