Preventing relapse in recurrent depression using mindfulness-based cognitive therapy, antidepressant medication or the combination trial design and protocol of the MOMENT study 英文参考文献.docVIP

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Preventing relapse in recurrent depression using mindfulness-based cognitive therapy, antidepressant medication or the combination trial design and protocol of the MOMENT study 英文参考文献.doc

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Preventing relapse in recurrent depression using mindfulness-based cognitive therapy, antidepressant medication or the combination trial design and protocol of the MOMENT study 英文参考文献

Huijbersetal.BMCPsychiatry2012,12:125 /1471-244X/12/125 STUDY PROTOCOL OpenAccess Preventingrelapseinrecurrentdepressionusing mindfulness-basedcognitivetherapy, antidepressantmedicationorthecombination: trialdesignandprotocoloftheMOMENTstudy MarloesJHuijbers1*,JanSpijker2,ARogierTDonders3,DignaJFvanSchaik4,PatriciavanOppen4, HenricusGRuhé5,MarcBJBlom6,WillemANolen7,JohanOrmel7,GertJanvanderWilt3,WillemKuyken8, PhilipSpinhoven9andAnneEMSpeckens1 Abstract Background:Depressionisacommonpsychiatricdisordercharacterizedbyahighrateofrelapseandrecurrence. Themostcommonlyusedstrategytopreventrelapse/recurrenceismaintenancetreatmentwithantidepressant medication(mADM).Recently,ithasbeenshownthatMindfulness-BasedCognitiveTherapy(MBCT)isatleastas effectiveasmADMinreducingtherelapse/recurrencerisk.However,itisnotyetknownwhethercombination treatmentofMBCTandmADMismoreeffectivethaneitherofthesetreatmentsalone.Giventhefactthatmost patientshaveapreferenceforeithermADMorforMBCT,theaimofthepresentstudyistoanswerthefollowing questions.First,whatistheeffectivenessofMBCTinadditiontomADM?Second,howlargeistheriskofrelapse/ recurrenceinpatientswithdrawingfrommADMafterparticipatinginMBCT,comparedtothosewhocontinueto usemADMafterMBCT? Methods/design:Twoparallel-group,multi-centerrandomizedcontrolledtrialsareconducted.Adultpatientswith ahistoryofdepression(3ormoreepisodes),currentlyeitherinfullorpartialremissionandcurrentlytreatedwith mADM(6monthsorlonger)arerecruited.Inthefirsttrial,wecomparemADMonitsownwithmADMplusMBCT. Inthesecondtrial,wecompareMBCTonitsown,includingtaperingofmADM,withmADMplusMBCT.Follow-up assessmentsareadministeredat3-monthintervalsfor15months.Primaryoutcomeisrelapse/recurrence. Secondaryoutcomesaretimeto,durationandseverityofrelapse/recurrence,qualityoflife,personality,several processvariables,andincrementalcost-effectivenessratio. Discussion:Takingintoaccountpatientpreferences,thisstudywillprovideinformationabouta)theclinicaland cost-effectivenessofmADMonlycomparedwit