Proanthocyanidins from Grape Seeds Modulate the NF-κB Signal Transduction Pathways in Rats with TNBS-Induced Ulcerative Colitis 英文参考文献.docVIP

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Proanthocyanidins from Grape Seeds Modulate the NF-κB Signal Transduction Pathways in Rats with TNBS-Induced Ulcerative Colitis 英文参考文献.doc

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Proanthocyanidins from Grape Seeds Modulate the NF-κB Signal Transduction Pathways in Rats with TNBS-Induced Ulcerative Colitis 英文参考文献

Molecules 2011, 16, 6721-6731; doi:10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Proanthocyanidins from Grape Seeds Modulate the NF-κB Signal Transduction Pathways in Rats with TNBS-Induced Ulcerative Colitis Xiaoli Li 1,3, Xiaolai Yang 2, Yongqing Cai 4, Hong Qin 1, Li Wang 1, Yanhong Wang 2, Yanhui Huang 1, Xiaoxia Wang 1, Shuai Yan 1, Liping Wang 1, Xin Zhao 1,Wan Li 1, Sijia Li 1, Jiajia Chen 1 and Yongjie Wu 1,* 1 Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Department of College of Medicine, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China 2 People’s Hospital of Gansu Province, Lanzhou 730000, China 3 Department of Pharmacology, College of Medicine, The Third Military Medical University, Chongqing 400038, China 4 Department of Pharmacy, Southwestern Hospital, The Third Military Medical University, Chongqing 400038, China * Author to whom correspondence should be addressed; E-Mail: wuyj@. Received: 5 July 2011; in revised form: 29 July 2011 / Accepted: 3 August 2011 / Published: 8 August 2011 Abstract: To elucidate the molecular mechanisms involved in the therapeutic effects of proanthocyanidins from grape seeds (GSPE), we explore whether GSPE regulates the inflammatory response of TNBS-induced colitis in rats at the levels of NF-κB signal transduction pathway. Rats were intragastrically administered of different doses of GSPE (100, 200 and 400 mg·kg?1) per day for seven days after ulcerative colitis (UC) was induced by intracolonic injection of 2,4,6-trinitrobenzenesulfonic acid (TNBS) dissolved in 50% ethanol. Sulfasalazine (SASP) at 400 mg/kg was used as a positive control drug. The expression of nuclear factor-kappa B (NF-κB), phospho-I kappaB-alpha (pIκBα), inhibitor kappa B kinase (IκK) in the colon tissues were all measured by enzyme-linked immunosorbent assay (ELISA) methods. Treatment with GSPE redu