Probability of ventricular fibrillation allometric model based on the ST deviation 英文参考文献.docVIP
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Probability of ventricular fibrillation allometric model based on the ST deviation 英文参考文献
Bonominietal.BioMedicalEngineeringOnLine2011,10:2
/content/10/1/2
RESEARCH
OpenAccess
Probabilityofventricularfibrillation:allometric
modelbasedontheSTdeviation
MariaPBonomini1,PedroDArini 1,2,MaxEValentinuzzi1*
*Correspondence:
maxvalentinuzzi@.ar
1InstitutodeIngenieríaBiomédica
(IIBM),FacultaddeIngeniería(FI),
UniversidaddeBuenosAires(UBA),
Abstract
Background:Allometry,ingeneralbiology,measurestherelativegrowthofapartin
relationtothewholelivingorganism.Usingreportedclinicaldata,weapplythis
BuenosAires,Argentina.
conceptforevaluatingtheprobabilityofventricularfibrillationbasedonthe
electrocardiographicST-segmentdeviationvalues.
Methods:Datacollectedbypreviousreportswereusedtofitanallometricmodelin
ordertoestimateventricularfibrillationprobability.Patientspresentingeitherwith
death,myocardialinfarctionorunstableanginawereincludedtocalculatesuch
probabilityas,VFp=δ+b(ST),forthreedifferentSTdeviations.Thecoefficientsδ
andbwereobtainedasthebestfittotheclinicaldataextendedoverobservational
periodsof1,6,12and48monthsfromoccurrenceofthefirstreportedchestpain
accompaniedbySTdeviation.
Results:Byapplicationoftheaboveequationinlog-logrepresentation,thefitting
procedureproducedthefollowingoverallcoefficients:Averageb=0.46,witha
maximum=0.62andaminimum=0.42;Averageδ=1.28,withamaximum=1.79
andaminimum=0.92.Fora2mmST-deviation,thefullrangeofpredicted
ventricularfibrillationprobabilityextendedfromabout13%at1monthupto86%at
4yearsaftertheoriginalcardiacevent.
Conclusions:Theseresults,atleastpreliminarily,appearacceptableandstillcallfor
fullclinicaltest.Themodelseemspromising,especiallyifotherparameterswere
takenintoaccount,suchasbloodcardiacenzymeconcentrations,ischemicor
infarctedepicardialareasorejectionfraction.Itisconcluded,consideringthese
resultsandafewreferencesfoundintheliterature,thattheallometricmodelshows
goodpredictivepracticalvaluetoaidmedicaldecisions.
Background
Ventricularfibrillationcanbeviewedasaprobabilisticeventthatappearsbiasedunder
certainpathophysiolog
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