Primary pleural angiosarcoma as a mimicker of mesothelioma a case report 英文参考文献.docVIP

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Primary pleural angiosarcoma as a mimicker of mesothelioma a case report 英文参考文献.doc

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Primary pleural angiosarcoma as a mimicker of mesothelioma a case report 英文参考文献

Kaoetal.DiagnosticPathology2011,6:130 /content/6/1/130 CASE REPORT OpenAccess Primarypleuralangiosarcomaasamimickerof mesothelioma:acasereport Yu-ChienKao1,Jyh-MingChow2,Kum-MinWang3,Chia-LangFang1,Jan-ShowChu4andChi-LongChen1* Abstract Primarypleuralangiosarcomaisarareandclinicallyaggressivetumor.Patientsusuallypresentwithchestpain, dyspnea,hemoptysisand/orcough.Radiologicstudiesrevealdiffusepleuralthickeningandpleuraleffusionwithor withoutmasslesion.Theclinicalandradiologicalfeaturesbothresemblethoseofmesothelioma,anditsdefinite diagnosisrequirescarefulhistologicexamination.However,frequentepithelioidfeatureandimmunoreactivityto cytokeratininprimarypleuralangiosarcomafurthercomplicatethepathologicdiagnosis.Theuseofproper immunohistochemicalstainsisoftenneededtosupportendothelialdifferentiationinthetumorcellsandto excludemetastaticcarcinomaandmesothelioma.Wereportthecaseofa49-year-oldmalepatientwithprimary pleuralangiosarcoma,whopresentedwithinitialhemothorax,followedbyarapidprogresstoaninoperablestatus. VirtualSlides:Thevirtualslide(s)forthisarticlecanbefoundhere:http://www.diagnosticpathology.diagnomx.eu/ vs/1059343251633446 Keywords:angiosarcoma,pleura,mesothelioma,sarcoma,pathology Background We describe herein a case of PPA, to highlight its Angiosarcoma is an uncommon malignant tumor of aggressiveclinicalbehaviorandthediagnosticpitfalls. endothelial differentiation. It accounts for about 1% of all soft tissue malignancies and most commonly arises Casepresentation inskin,softtissue,breast,liver,boneandspleen[1]. Clinical summary Primary pleural angiosarcoma (PPA) is a rare occur- A49year-old-male patient presented withintermittent rence. Since its first description in 1943,[2] only 39 right chest pain for one month. The pain progressed reported cases of PPA have been published [1-22]. with exertional dyspnea. He had a 10-year history of Patientsalmostalwaysdieofthediseasewithinmonths. asthmaunderregularmedicaltreatmentandwasanex- Definite diagnos