Probiotic Ferulic Acid Esterase Active Lactobacillus fermentum NCIMB 5221 APA Microcapsules for Oral Delivery Preparation and in Vitro Characterization 英文参考文献.docVIP

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Probiotic Ferulic Acid Esterase Active Lactobacillus fermentum NCIMB 5221 APA Microcapsules for Oral Delivery Preparation and in Vitro Characterization 英文参考文献.doc

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Probiotic Ferulic Acid Esterase Active Lactobacillus fermentum NCIMB 5221 APA Microcapsules for Oral Delivery Preparation and in Vitro Characterization 英文参考文献

Pharmaceuticals 2012, 5, 236-248; doi:10.3390/ph5020236 OPEN ACCESS Pharmaceuticals ISSN 1424-8247 /journal/pharmaceuticals Article Probiotic Ferulic Acid Esterase Active Lactobacillus fermentum NCIMB 5221 APA Microcapsules for Oral Delivery: Preparation and in Vitro Characterization Catherine Tomaro-Duchesneau 1, Shyamali Saha 2, Meenakshi Malhotra 1, Michael Coussa-Charley 1, Imen Kahouli 3, Mitchell L. Jones 4, Alain Labbé 4 and Satya Prakash 1,* 1 Biomedical Technology and Cell Therapy Research Laboratory, Departments of Biomedical Engineering, Physiology, and Artificial Cells and Organs Research Center, Faculty of Medicine, McGill University, 3775 University Street, Montreal, Quebec, H3A 2B4, Canada; E-Mails: catherine.tomaro-duchesneau@mail.mcgill.ca (C.T.-D.); meenakshi.malhotra@mail.mcgill.ca (M.M.); michael.coussa-charley@mail.mcgill.ca (M.C.-C.) 2 Faculty of Dentistry, McGill University, 3775 University Street, Montreal, Quebec, H3A 2B4, Canada; E-Mail: shyamali.saha@mail.mcgill.ca 3 Department of Experimental Medicine, McGill University, 3775 University Street, Montreal, Quebec, H3A 2B4, Canada; E-Mail: imen.kahouli@mail.mcgill.ca 4 Micropharma Limited, 141 President Kennedy Ave., UQAM Biological Sciences Building, 5th Floor, Suite 5569, Montreal, Quebec, H2X 3Y7, Canada; E-Mails: mitchell@ (M.L.J.); alain@ (A.L.) * Author to whom correspondence should be addressed; E-Mail: satya.prakash@mcgill.ca; Tel.: +1-514-398-3676; Fax: +1-514-398-7461. Received: 23 December 2011; in revised form: 3 February 2012 / Accepted: 10 February 2012 / Published: 16 February 2012 Abstract: Probiotics possess potential therapeutic and preventative effects for various diseases and metabolic disorders. One important limitation for the oral delivery of probiotics is the harsh conditions of the upper gastrointestinal tract (GIT) which challenge bacterial viability and activity. One proposed method to surpass this obstacle is the use of m