Probiotics in treatment of allergic rhinitis 英文参考文献.docVIP

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Probiotics in treatment of allergic rhinitis 英文参考文献.doc

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Probiotics in treatment of allergic rhinitis 英文参考文献

REVIEWS ProbioticsinTreatmentofAllergicRhinitis RashmiRanjanDas,MD,1 MeenuSingh,MD,FIAP,FCCP,2 andNusratSha?q,MD,DM3 viewsshowsthatprobioticsarebene?cialfortreatinginfec- Abstract: Many randomized controlled trials (RCTs) have been tiousdiarrhea,preventingantibiotic-associateddiarrhea,and doneonroleofprobioticsasatreatmentmodalityinallergicrhinitis. treating vaginal infections in pregnancy. They have been 3–5 We conducted a review on the same. A systematic search of publishedliteraturewasdone.RCTscomparingeffectofprobiotics withplacebowereincluded.Aprede?nedsetofoutcomemeasures wereassessed.Continuousdatawereexpressedaspooledstandard- ized mean difference (SMD) with 95% con?dence interval (CI). Dichotomous data were expressed as odds ratio with 95% CI. P value?0.05wasconsideredsigni?cant.RevManversion5wasused foralltheanalyses.SevenRCTswereeligibleforinclusion.Probi- otic intake improved quality of life score in patients with allergic rhinitis[SMD?1.17(95%CI?1.47,?0.86;P?0.00001)].Other parameterthatimprovedwithprobioticintakewasdecreaseinthe number of episodes of rhinitis per year. There was no signi?cant changeinbloodorimmunologicparametersintheprobioticgroup, SMD?0.10(95%CI?0.26,0.06;P?0.22).Adverseeventswere notsigni?cant.Probiotictherapymightbeusefulinrhinitis,butthe presentdatadonotallowanytreatmentrecommendations. formally investigated in a number of clinical trials for the treatmentofseasonalandperennialARwithvariableresults. Theaimofthepresentpaperisto?ndwhetherprobioticsare effectiveintreatmentofARornot. METHOD CriteriaforConsideringStudiesforThisReview TypesofStudies Randomized double-blind placebo-controlled trials (RCTs). TypesofParticipants Participantsintrialswereofeithersexandofanyage. TypesofInterventions KeyWords:respiratoryallergy,lactobacillus,qualityoflife, bio?dobacterium,clinicaltrials Interventions consisted of daily treatment with probi- oticsorplacebo(noprobioticbacteria),usedfor? 2weeks, as an additive to standard antiallergic medic