Procalcitonin to guide duration of antibiotic therapy in intensive care patients a randomized prospective controlled trial 英文参考文献.docVIP

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Procalcitonin to guide duration of antibiotic therapy in intensive care patients a randomized prospective controlled trial 英文参考文献.doc

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Procalcitonin to guide duration of antibiotic therapy in intensive care patients a randomized prospective controlled trial 英文参考文献

Available online /content/13/3/R83 Research Open Access Vol 13 No 3 Procalcitonin to guide duration of antibiotic therapy in intensive care patients: a randomized prospective controlled trial Marcel Hochreiter1, Thomas K?hler1, Anna Maria Schweiger2, Fritz Sixtus Keck2,3, Berthold Bein4, Tilman von Spiegel1 and Stefan Schroeder1 1Department of Anesthesiology and Intensive Care Medicine, West Coast Hospital, Esmarchstrasse 50, 25746 Heide, Germany 2Department of Laboratory Medicine and Clinical Chemistry, West Coast Hospital, Esmarchstrasse 50, 25746 Heide, Germany 3Medical Clinic, West Coast Hospital, Esmarchstr. 50, 25746 Heide, Germany 4Department of Anesthesiology and Intensive Care Medicine, University Hospital Schleswig-Holstein, Campus Kiel, Schwanenweg 21, 24105 Kiel, Germany Corresponding author: Stefan Schroeder, sschroeder@wkk-hei.de Received: 24 Feb 2009 Revisions requested: 18 Mar 2009 Revisions received: 21 Mar 2009 Accepted: 3 Jun 2009 Published: 3 Jun 2009 Critical Care 2009, 13:R83 (doi:10.1186/cc7903) This article is online at: /content/13/3/R83 ? 2009 Hochreiter et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction The development of resistance by bacterial species is a compelling issue to reconsider indications and administration of antibiotic treatment. Adequate indications and duration of therapy are particularly important for the use of highly potent substances in the intensive care setting. Until recently, no laboratory marker has been available to differentiate bacterial infection from viral or non-infectious inflammatory reaction; however, over the past years, procalcitonin (PCT) is the first among a large array of inflammatory variables that offe