Procon clinical debate Antibiotics are important in the management of patients with pancreatitis with evidence of pancreatic necrosis 英文参考文献.docVIP

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Procon clinical debate Antibiotics are important in the management of patients with pancreatitis with evidence of pancreatic necrosis 英文参考文献.doc

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Procon clinical debate Antibiotics are important in the management of patients with pancreatitis with evidence of pancreatic necrosis 英文参考文献

Available online /content/7/5/351 Review Pro/con clinical debate: Antibiotics are important in the management of patients with pancreatitis with evidence of pancreatic necrosis Graham Ramsay1, Paul Breedveld2, Lorne H Blackbourne3 and Stephen M Cohn4 1Professor and Chief of Intensive Care and Accident Department, University Hospital Maastricht, The Netherlands 2Trauma Surgeon and Intensivist, University Hospital Maastricht, The Netherlands 3Fellow in Trauma and Surgical Critical Care, University of Miami School of Medicine, Ryder Trauma Center, Miami, FL, USA 4The Robert Zeppa Professor of Surgery, Chief, Divisions of Trauma and Surgical Critical Care, University of Miami School of Medicine and Medical Director, Ryder Trauma Center, Miami, FL, USA Correspondence: Critical Care Editorial Office, editorial@ Published online: 17 March 2003 Critical Care 2003, 7:351-353 (DOI 10.1186/cc2165) This article is online at /content/7/5/351 ? 2003 BioMed Central Ltd (Print ISSN 1364-8535; Online ISSN 1466-609X) Abstract Pancreatitis is not an infrequent diagnosis in patients admitted to the intensive care unit. Prolonged stays, intense resource utilization and high morbidity/mortality are commonplace in such patients. Management for the most part is supportive, with the surgical team keeping close watch to intervene as the need arises. Over the past few decades there has been considerable debate regarding the usefulness of systemic antibiotics to prevent infectious complications in patients with evidence of pancreatic necrosis. In the present article of Critical Care, two expert groups debate the two sides of this contentious antibiotic issue. Keywords antibiotic prophylaxis, critical care, multiorgan failure, pancreatic necrosis, pancreatitis The scenario A 29-year-old male develops severe pancreatitis, presum- and, in the course of investigation, he has an abdominal computed tomography scan that shows an inflamed