Pro-atrial natriuretic peptide is a prognostic marker in sepsis, similar to the APACHE II score an observational study 英文参考文献.docVIP

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Pro-atrial natriuretic peptide is a prognostic marker in sepsis, similar to the APACHE II score an observational study 英文参考文献.doc

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Pro-atrial natriuretic peptide is a prognostic marker in sepsis, similar to the APACHE II score an observational study 英文参考文献

Available online /content/9/1/R37 Research Open Access February 2005 Vol 9 No 1 Pro-atrial natriuretic peptide is a prognostic marker in sepsis, similar to the APACHE II score: an observational study Nils G Morgenthaler1, Joachim Struck1, Mirjam Christ-Crain2, Andreas Bergmann1 and Beat Müller2 1Research Department, BRAHMS AG, Biotechnology Center, Hennigsdorf/Berlin, Germany 2Department of Internal Medicine, University Hospital, Basel, Switzerland Corresponding author: Beat Müller, happymiller@ Received: 7 September 2004 Critical Care 2005, 9:R37-R45 (DOI 10.1186/cc3015) This article is online at: /content/9/1/R37 Revisions requested: 12 October 2004 Revisions received: 4 November 2004 Accepted: 5 November 2004 ? 2004 Morgenthaler et al., licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/ licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is cited. Published: 17 December 2004 Abstract Introduction Additional biomarkers in sepsis are needed to tackle the challenges of determining prognosis and optimizing selection of high-risk patients for application of therapy. In the present study, conducted in a cohort of medical intensive care unit patients, our aim was to compare the prognostic value of mid-regional pro-atrial natriuretic peptide (ANP) levels with those of other biomarkers and physiological scores. Methods Blood samples obtained in a prospective observational study conducted in 101 consecutive critically ill patients admitted to the intensive care unit were analyzed. The prognostic value of pro-ANP levels was compared with that of the Acute Physiology and Chronic Health Evaluation (APACHE) II score and with those of various biomarkers (i.e. C-reactive protein, IL-6 and procalcitonin). Mid-regional pro-ANP was detected in EDTA plasma from all patients using a new sandwich immuno