Primary endometrioid adenocarcinoma of the cervix with widespread squamous metaplasia – a potential diagnostic pitfall 英文参考文献.docVIP

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Primary endometrioid adenocarcinoma of the cervix with widespread squamous metaplasia – a potential diagnostic pitfall 英文参考文献.doc

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Primary endometrioid adenocarcinoma of the cervix with widespread squamous metaplasia – a potential diagnostic pitfall 英文参考文献

Diagnostic Pathology BioMedCentral Case Report Open Access Primary endometrioid adenocarcinoma of the cervix with widespread squamous metaplasia – a potential diagnostic pitfall Lynn Hirschowitz*1, Chandan Sen1 and John Murdoch2 Address: 1Department of Cellular Pathology, Southmead Hospital, Bristol, BS10 5NB, UK and 2Department of Gynaecological Oncology, St Michaels Hospital, Southwell Street, Bristol BS2 8EG, UK Email: Lynn Hirschowitz* - lynnlove@.uk; Chandan Sen - chandan.sen@nbt.nhs.uk; John Murdoch - john.murdoch@ubht.nhs.uk * Corresponding author Published: 25 October 2007 Received: 17 September 2007 Accepted: 25 October 2007 Diagnostic Pathology 2007, 2:40 doi:10.1186/1746-1596-2-40 This article is available from: /content/2/1/40 ? 2007 Hirschowitz et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Uterine or endocervical biopsies that contain endometrioid adenocarcinoma with widespread squamous metaplasia are usually of endometrial origin. The presence of squamous metaplasia is said to be helpful in distinguishing endocervical from endometrial adenocarcinomas in small biopsy samples. Case presentation: A 51-year-old woman presented with post-coital and post-menopausal bleeding. Biopsy of a friable lesion in the proximal endocervical canal revealed an endocervical adenocarcinoma of endometrioid type with widespread squamous metaplasia. The latter feature initially raised the possible diagnosis of a primary endometrial adenocarcinoma. However, immunohistochemical marker studies indicated a diagnosis of primary endocervical adenocarcinoma of endometrioid type and this was confirmed at hysterectomy. Conclusion: Squamous differentiation is not we