Prevalence of Trachoma in Unity State, South Sudan Results from a Large-Scale Population-Based Survey and Potential Implications for Further Surveys 英文参考文献.docVIP

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Prevalence of Trachoma in Unity State, South Sudan Results from a Large-Scale Population-Based Survey and Potential Implications for Further Surveys 英文参考文献.doc

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Prevalence of Trachoma in Unity State, South Sudan Results from a Large-Scale Population-Based Survey and Potential Implications for Further Surveys 英文参考文献

PrevalenceofTrachomainUnityState,SouthSudan: ResultsfromaLarge-ScalePopulation-BasedSurveyand PotentialImplicationsforFurtherSurveys TansyEdwards1,JenniferSmith2,HughJ.W.Sturrock2,LuciaW.Kur3,AnthonySabasio4, TimothyP.Finn4,MounirLado3,DannyHaddad5,JanH.Kolaczinski2,6* 1MedicalResearchCouncilTropicalEpidemiologyGroup,DepartmentofEpidemiologyandPopulationHealth,LondonSchoolofHygieneandTropicalMedicine,London, UnitedKingdom,2DepartmentofInfectiousandTropicalDiseases,LondonSchoolofHygieneandTropicalMedicine,London,UnitedKingdom,3MinistryofHealth,Juba, Republic of South Sudan, 4Malaria Consortium South Sudan, Juba, Republic of South Sudan, 5International Trachoma Initiative, Decatur, Georgia, United States of America,6MalariaConsortiumAfricaRegionalOffice,Kampala,Uganda Abstract Background: Large partsof SouthSudanarethought tobetrachoma-endemic butbaseline dataarelimited.Thisstudy aimedtoestimateprevalenceforplanningtrachomainterventionsinUnityState,toidentifyriskfactorsandtoinvestigate theeffectofdifferentsamplingapproachesonstudyconclusions. MethodsandFindings:ThesurveyareawasdefinedasonedomainofeightcountiesinUnityState.Acrossthearea,40 clusters (villages) were randomly selected proportional to the county population size in a population-based prevalence survey. The simplified grading scheme was used to classify clinical signs of trachoma. The unadjusted prevalence of trachomainflammation-follicular(TF)inchildrenaged1–9yearswas70.5%(95%CI:68.6–72.3).Afteradjustingforage,sex, countyandclusteringofcasesathouseholdandvillageleveltheprevalencewas71.0%(95%CI:69.9–72.1).Theprevalence of trachomatous trichiasis (TT) in adults was 15.1% (95% CI: 13.4–17.0) and 13.5% (95% CI: 12.0–15.1) before and after adjustment, respectively. We estimate that 700,000 people (the entire population of Unity State) require antibiotic treatmentandapproximately54,178peoplerequireTTsurgery.Riskfactoranalysesconfirmedchild-levelassociationswith TF and highlighted that older adults living in p