Preventing autoimmune arthritis using antigen-specific immature dendritic cells a novel tolerogenic vaccine 英文参考文献.docVIP

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Preventing autoimmune arthritis using antigen-specific immature dendritic cells a novel tolerogenic vaccine 英文参考文献.doc

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Preventing autoimmune arthritis using antigen-specific immature dendritic cells a novel tolerogenic vaccine 英文参考文献

Available online /content/8/5/R141 Research article Open Access Vol 8 No 5 Preventing autoimmune arthritis using antigen-specific immature dendritic cells: a novel tolerogenic vaccine Igor Popov1, Mu Li1, Xiufen Zheng1, Hongtao San1, Xusheng Zhang1, Thomas E Ichim1, Motohiko Suzuki1, Biao Feng1, Costin Vladau1, Robert Zhong1,2,3,4, Bertha Garcia1,3, Gill Strejan1, Robert D Inman5 and Wei-Ping Min1,2,3,4 1Department of Surgery, Microbiology and Immunology, and Pathology, London Health Science Centre, London, Canada 2Multi-Organ Transplant Program, London Health Science Centre, London, Canada 3Immunology and Transplantation, Lawson Health Research Institute, London, Canada 4Robarts Research Institute, London, Canada 5Division of Rheumatology, Department of Medicine, Toronto Western Hospital, University Health Network, Toronto, Canada Corresponding author: Wei-Ping Min, mweiping@uwo.ca Received: 9 Mar 2006 Revisions requested: 11 Apr 2006 Revisions received: 18 Jul 2006 Accepted: 15 Aug 2006 Published: 15 Aug 2006 Arthritis Research Therapy 2006, 8:R141 (doi:10.1186/ar2031) This article is online at: /content/8/5/R141 ? 2006 Popov et al., licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Conventional treatments for autoimmune diseases have relied heavily on nonspecific immune suppressants, which possess a variety of adverse effects without inhibiting the autoimmune process in a specific manner. In the present study we demonstrate the effectiveness of antigen-specific, maturation- resistant, tolerogenic dendritic cells (DC) in suppressing collagen-induced arthritis, a murine model of rheumatoid arthritis. Treatment of DC progenitors with the NF-κB inhibiting agent LF 15-0195 (LF)