Prevalence Study of Yaws in the Democratic Republic of Congo Using the Lot Quality Assurance Sampling Method 英文参考文献.docVIP

PrevalenceStudyofYawsintheDemocraticRepublicof CongoUsingtheLotQualityAssuranceSampling Method SibylleGerstl1*,Ge′deonKiwila2,MehulDhorda1,2,SylvaineLonlas2,MarkMyatt3,Beno??tKebelaIlunga4, DenisLemasson2,ElisabethSzumilin2,PhilippeJ.Guerin1,LaurentFerradini1 1Epicentre,Paris,France,2Me′decins sansFrontie`res-France,Paris,France,3DivisionofEpidemiology,InstituteofOphthalmology,UniversityCollegeLondon,London, UnitedKingdom,4MinistryofHealth,Kinshasa,DemocraticRepublicoftheCongo Abstract Background: Until the 1970s the prevalence of non-venereal trepanomatosis, including yaws, was greatly reduced after worldwidemasstreatment.In2005,caseswereagainreportedintheDemocraticRepublicoftheCongo.Wecarriedouta surveytoestimatethevillage-levelprevalenceofyawsintheregionofEquatorinthenorthofthecountryinordertodefine appropriatestrategiestoeffectivelytreattheaffectedpopulation. Methodology/Principal Findings: We designed a community-based survey using the Lot Quality Assurance Sampling methodtoclassifytheprevalenceofactiveyawsin14groupsofvillages(lots).Theclassificationintohigh,moderate,orlow yawsprevalencecorrespondedtoWorldHealthOrganizationprevalencethresholdsforidentifyingappropriateoperational treatment strategies. Active yaws cases were defined by suggestive clinical signs and positive rapid plasma reagin and Treponemapallidumhemagglutinationserologicaltests.Theoverallprevalenceinthestudyareawas4.7%(95%confidence interval:3.4–6.0).Twoof14lotshadhighprevalence(.10%),threemoderateprevalence(5–10%)andninelowprevalence (,5%.). Conclusions/Significance:AlthoughyawsisnolongeraWorldHealthOrganizationprioritydisease,thepresenceofyawsin a region where it was supposed to be eradicated demonstrates the importance of continued surveillance and control efforts. Yaws should remain a public health priority in countries where previously it was known to be endemic. The integration of sensitive surveillance systems together with free access to effective treatment is recommended. As a cons