Primary colorectal small cell carcinoma A clinicopathological and immunohistochemical study of 10 cases 英文参考文献.docVIP

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Primary colorectal small cell carcinoma A clinicopathological and immunohistochemical study of 10 cases 英文参考文献.doc

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Primary colorectal small cell carcinoma A clinicopathological and immunohistochemical study of 10 cases 英文参考文献

Diagnostic Pathology BioMedCentral Research Open Access Primary colorectal small cell carcinoma: A clinicopathological and immunohistochemical study of 10 cases Dina El Demellawy1, Mahmoud A Khalifa*2, Nadia Ismiil2, Shun Wong3 and Zeina Ghorab2 Address: 1Department of Pathology, Thunder Bay Regional Health Sciences Center, 1874 Oliver Road, Thunder Bay, Ontario P7G 1P1, Canada, 2Department of Pathology, Sunnybrook Health Sciences Center, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada and 3Department of Radiation Oncology, Sunnybrook Health Sciences Center, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada Email: Dina El Demellawy - dina_eldemellawy@; Mahmoud A Khalifa* - mahmoud.khalifa@sunnybrook.ca; Nadia Ismiil - nadia.ismiil@sunnybrook.ca; Shun Wong - shun.wong@sunnybrook.ca; Zeina Ghorab - zeina.ghorab@sunnybrook.ca * Corresponding author Published: 5 September 2007 Received: 9 July 2007 Accepted: 5 September 2007 Diagnostic Pathology 2007, 2:35 doi:10.1186/1746-1596-2-35 This article is available from: /content/2/1/35 ? 2007 El Demellawy et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Colorectal small cell carcinoma (SmCC) is a rare tumor with an aggressive course. The aim of this study is to summarize our experience with this tumor and to highlight its immunohistochemical profile. Ten cases of colorectal SmCC were identified in our files and a panel of immunostains was performed. Follow up was available for the average of 3 years, during which 7 patients died and 3 were alive with disease. All cases were positive for LMWK, CK 19 and pancytokeratin but were negative for TTF-1 and CA 125. EGFR was positive in 7 cases. TTF-1 negative staining may be valuable in differen