Primary lymphocutaneous nocardiosis in an immunocompetent patient 英文参考文献.docVIP

Annals of Clinical Microbiology and Antimicrobials BioMedCentral Case report Open Access Primary lymphocutaneous nocardiosis in an immunocompetent patient Sofia Maraki*1, Stavros Chochlidakis2, Eleni Nioti1 and Yannis Tselentis1 Address: 1Department of Clinical Bacteriology, Parasitology, Zoonoses and Geographical Medicine, University Hospital of Crete, 712 01 Heraklion, Crete, Greece and 2Department of Orthopedics, University Hospital of Crete, 712 01 Heraklion, Crete, Greece Email: Sofia Maraki* - sofiamaraki@in.gr; Stavros Chochlidakis - sv9sk@med.uoc.gr; Eleni Nioti - sofiamaraki@in.gr; Yannis Tselentis - tselendi@med.uoc.gr * Corresponding author Published: 15 November 2004 Received: 23 September 2004 Accepted: 15 November 2004 Annals of Clinical Microbiology and Antimicrobials 2004, 3:24 doi:10.1186/1476-0711-3-24 This article is available from: /content/3/1/24 ? 2004 Maraki et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Nocardia brasiliensis is a rare human pathogen usually associated with localized cutaneous infections. Case Presentation: We report a case of primary lymphocutaneous Nocardia brasiliensis infection developed after a bone fracture of the left hand of an otherwise healthy 32-year-old man. Treatment with trimethoprim-sulfamethoxazole given for a total of three months combined with surgical debridement resulted in complete resolution of the infection. Conclusion: Nocardiosis should be part of the differential diagnosis in patients with sporotrichoid infection, particularly those with a history of outdoor injury. Culture of the affected tissue and antimicrobial susceptibility testing of the isolate should be performed for diagnosis and tre