Primary and secondary transcriptional effects in the developing human Down syndrome brain and heart 英文参考文献.docVIP

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Primary and secondary transcriptional effects in the developing human Down syndrome brain and heart 英文参考文献.doc

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Primary and secondary transcriptional effects in the developing human Down syndrome brain and heart 英文参考文献

Open Access Re rch 2005MaoetVoal.lumesea6, Issue 13, Article R107 Primary and secondary transcriptional effects in the developing human Down syndrome brain and heart Rong Mao*?, Xiaowen Wang?, Edward L Spitznagel Jr§, Laurence P Frelin?, Jason C Ting?, Huashi Ding?, Jung-whan Kim￥, Ingo Ruczinski#, Thomas J Downey? and Jonathan Pevsner*??￥ Addresses: *Program in Biochemistry, Cellular and Molecular Biology, Johns Hopkins School of Medicine, 1830 East Monument Street, Baltimore, MD 21205, USA. ?Department of Neuroscience, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA. ?Partek Incorporated, St Charles, MO 63304, USA. §Department of Mathematics, Campus Box 1146, Washington University, St Louis, MO 63130, USA. ?Department of Neurology, Kennedy Krieger Institute, 707 North Broadway, Baltimore, MD 21205, USA. ￥Pathobiology Graduate Program, Johns Hopkins School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA. #Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA. Correspondence: Jonathan Pevsner. E-mail: pevsner@ Published: 16 December 2005 Received: 26 July 2005 Revised: 4 October 2005 Accepted: 21 November 2005 Genome Biology 2005, 6:R107 (doi:10.1186/gb-2005-6-13-r107) The electronic version of this article is the complete one and can be found online at /2005/6/13/R107 ? 2005 Mao et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ProfilingchproMmiocsroohumanmarera2y1agDownneanleyseixsSyndromepofretranscriptssion./plevels in fetal cerebellum and heart tissues of Down Syndrome patients showed a disruption only of Abstract Background: Down syndrome, caused by trisomic chromosome 21, is the leading gen