Profile of Central and Effector Memory T Cells in the Progression of Chronic Human Chagas Disease 英文参考文献.docVIP

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Profile of Central and Effector Memory T Cells in the Progression of Chronic Human Chagas Disease 英文参考文献.doc

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Profile of Central and Effector Memory T Cells in the Progression of Chronic Human Chagas Disease 英文参考文献

ProfileofCentralandEffectorMemoryTCellsinthe ProgressionofChronicHumanChagasDisease JacquelineArau′joFiuza1,2,RicardoToshioFujiwara1,3,JulianaAssisSilvaGomes1,ManoelOta′viodas CostaRocha4,AnaTherezaChaves1,2,FernandaFortesdeArau′jo1,RafaelleChristineGomesFares1, AndreaTeixeira-Carvalho1,OlindodeAssisMartins-Filho1,GuilhermeGrossiLopesCanc?ado3 ,Rodrigo Correa-Oliveira1* 1CentrodePesquisasRene′ Rachou,FIOCRUZ,BeloHorizonte-MinasGerais,Brazil,2SantaCasadeMiserico′rdiadeBH,Po′s-graduac?a?oemBiomedicinaeCl?′nicaMe′dica, Belo Horizonte - Minas Gerais, Brazil, 3Departamento de Parasitologia, Instituto deCie?ncias Biolo′gicas, Universidade Federal deMinas Gerais, Belo Horizonte - Minas Gerais,Brazil,4FaculdadedeMedicina,ProgramadePo′s-graduac?a?o emCie?ncias daSau′de:InfectologiaeMedicinaTropical,UniversidadeFederaldeMinasGerais,Belo Horizonte-MinasGerais,Brazil Abstract Background:ChronicChagasdiseasepresentsseveraldifferentclinicalmanifestationsrangingfromasymptomatictosevere cardiac and/or digestive clinical forms. Several studies have demonstrated that immunoregulatory mechanisms are importantprocessesforthecontroloftheintenseimmuneactivityobservedinthechronicphase.Tcellsplayacriticalrole inparasitespecificandnon-specificimmuneresponseelicitedbythehostagainstTrypanosomacruzi.Specifically,memoryT cells,whicharebasicallyclassifiedascentralandeffectormemorycells,mighthaveadistinctmigratoryactivity,roleand functionduringthehumanChagasdisease. Methodology/PrincipalFindings:Basedonthehypothesisthatthediseaseseverityinhumansiscorrelatedtothequality + + ofimmuneresponsesagainstT.cruzi,weevaluatedthememoryprofileofperipheralCD4 andCD8 Tlymphocytesaswell asitscytokinesecretionbeforeandafterinvitroantigenicstimulation.Weevaluatedcellularresponsefromnon-infected individuals (NI), patients with indeterminate (IND) or cardiac (CARD) clinical forms of Chagas disease. The expression of CD45RA, CD45RO and CCR7 surface molecules was determined on CD4+ and CD8+ T lymphocytes