Procalcitonin kinetics within the first days of sepsis relationship with the appropriateness of antibiotic therapy and the outcome 英文参考文献.docVIP

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Procalcitonin kinetics within the first days of sepsis relationship with the appropriateness of antibiotic therapy and the outcome 英文参考文献.doc

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Procalcitonin kinetics within the first days of sepsis relationship with the appropriateness of antibiotic therapy and the outcome 英文参考文献

Available online /content/13/2/R38 Research Open Access Vol 13 No 2 Procalcitonin kinetics within the first days of sepsis: relationship with the appropriateness of antibiotic therapy and the outcome Pierre Emmanuel Charles1, Claire Tinel1, Saber Barbar1, Serge Aho2, Sébastien Prin1, Jean Marc Doise1, Nils Olivier Olsson3, Bernard Blettery1 and Jean Pierre Quenot1 1Service de Réanimation Médicale, H?pital Le Bocage, C.H.U. de Dijon, 21000 Dijon, France 2Service dEpidémiologie et dHygiène Hospitalière, H?pital Le Bocage, C.H.U. de Dijon, 21000 Dijon, France 3Laboratoire dImmunologie, H?pital Le Bocage, C.H.U. de Dijon, 21000 Dijon, France Corresponding author: Pierre Emmanuel Charles, pierre-emmanuel.charles@chu-dijon.fr Received: 2 Jan 2009 Revisions requested: 3 Feb 2009 Revisions received: 19 Feb 2009 Accepted: 16 Mar 2009 Published: 16 Mar 2009 Critical Care 2009, 13:R38 (doi:10.1186/cc7751) This article is online at: /content/13/2/R38 ? 2009 Charles et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Management of the early stage of sepsis is a critical issue. As part of it, infection control including appropriate antibiotic therapy administration should be prompt. However, microbiological findings, if any, are generally obtained late during the course of the disease. The potential interest of procalcitonin (PCT) as a way to assess the clinical efficacy of the empirical antibiotic therapy was addressed in the present study. greater rise in PCT between D1 and D2 was observed in patients with inappropriate antibiotics as compared with those with appropriate therapy (+5.2 (47.4) and +1.7 (35.0), respectively; P = 0.20). The D1 PCT level fail