Prognostic Significance of miR-181b and miR-21 in Gastric Cancer Patients Treated with S-1Oxaliplatin or DoxifluridineOxaliplatin 英文参考文献.docVIP
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Prognostic Significance of miR-181b and miR-21 in Gastric Cancer Patients Treated with S-1Oxaliplatin or DoxifluridineOxaliplatin 英文参考文献
PrognosticSignificanceofmiR-181bandmiR-21in
GastricCancerPatientsTreatedwithS-1/Oxaliplatinor
Doxifluridine/Oxaliplatin
JingtingJiang1,XiaoZheng1,XiaoXu2,QiZhou1,HaijiaoYan1,XueguangZhang3,BinfengLu4,
ChangpingWu1*,JingfangJu2*
1DepartmentofTumorBiologicalTreatment,TheThirdAffiliatedHospitalofSoochowUniversity,Changzhou,JiangsuProvince,People‘sRepublicofChina,2Department
ofPathology,StonyBrook University, StonyBrook, New York, United States ofAmerica, 3Key Laboratory ofStemCellof JiangsuProvince,Key Laboratory of Clinical
Immunology of Jiangsu Province, Soochow University, Suzhou, Jiangsu Province, People‘s Republic of China, 4Department of Immunology, University of Pittsburgh,
Pittsburgh,Pennsylvania,UnitedStatesofAmerica
Abstract
Background:ThegoalofthisstudyistoevaluatetheeffectivenessofS-1/Oxaliplatinvs.Doxifluridine/Oxaliplatinregimen
andtoidentifymiRNAsaspotentialprognosticbiomarkersingastriccancerpatients.TheexpressionofcandidatemiRNAs
wasquantifiedfromfifty-fivelatestagegastriccancerFFPEspecimens.
ExperimentalDesign:GastriccancerpatientswithKPS.70wererecruitedforthetrial.Thecontrolgroupwastreatedwith
400mg/twice/day Doxifluridine plus i.v. with Oxaliplatin at 130mg/m2/first day/4 week cycle. The testing group was
treatedwithS-1at40mg/twice/day/4weekcycleplusi.v.withOxaliplatinat130mg/m2/firstday/4weekcycle.TotalRNAs
wereextractedfromnormalandgastrictumorspecimens.ThelevelsofmiRNAswerequantifiedusingrealtimeqRT-PCR
expressionanalysis.
Results:Theoverallobjectiveresponserate(CR+PR)ofpatientstreatedwithS-1/Oxaliplatinwas33.3%(CR+PR)vs.17.6%
(CR+PR)withDoxifluridine/Oxaliplatinforadvancedstagegastriccancerpatients.Theaverageoverallsurvivalforpatients
treated with S-1/Oxaliplatin was 7.80 month vs. 7.30 month with patients treated with Doxifluridine/Oxaliplatin. The
expressionofmiR-181b(P=0.022)andmiR-21(P=0.0029)wassignificantlyoverexpressedingastrictumorscomparedto
normalgastrictissues.Kaplan-MeiersurvivalanalysisrevealedthatlowlevelsofmiR-21expression(Logra
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