Progressive Activation of CD127+132? Recent Thymic Emigrants into Terminally Differentiated CD127?132+ T-Cells in HIV-1 Infection 英文参考文献.docVIP

Progressive Activation of CD127+132? Recent Thymic Emigrants into Terminally Differentiated CD127?132+ T-Cells in HIV-1 Infection 英文参考文献.doc

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ProgressiveActivationofCD127132?RecentThymicEmigrantsintoTerminallyDifferentiatedCD127?132T-CellsinHIV-1Infection英文参考文献

ProgressiveActivationofCD127+1322RecentThymic EmigrantsintoTerminallyDifferentiatedCD1272132+ T-CellsinHIV-1Infection SarahC.Sasson1,2*,JohnJ.Zaunders2,NabilaSeddiki1,2,MichelleBailey1,2,KristinMcBride1,2,KerstenK. Koelsch1,2,KateM.Merlin2,DonE.Smith1,DavidA.Cooper1,2,AnthonyD.Kelleher1,2 1TheKirbyInstitute,TheUniversityofNewSouthWales,Sydney,Australia,2HIVImmunopathologyResearchLaboratory,StVincent’sHospitalCentreforAppliedMedical Research,Sydney,Australia Abstract Aim:HIVinfectionisassociatedwithdistortionofT-cellhomeostasisandtheIL-7/IL7Raxis.Progressiveinfectionresultsin lossofCD127+1322andgainsinCD1272132+CD4+andCD8+T-cells.WeinvestigatedthecorrelatesoflossofCD127 fromtheT-cellsurfacetounderstandmechanismsunderlyingthishomeostaticdysregulation. Methods:Peripheralandcordbloodmononuclearcells(PBMCs;CBMC)fromhealthyvolunteersandPBMCfrompatients with HIV infection were studied. CD127+1322, CD127+132+ and CD1272132+ T-cells were phenotyped by activation, differentiation,proliferationandsurvivalmarkers.CellularHIV-DNAcontentandsignal-jointT-cellreceptorexcisioncircles (sjTRECs)weremeasured. Results:CD127+1322T-cellswereenrichedforna?¨vecellswhileCD1272132+T-cellswereenrichedforactivated/terminally differentiatedT-cellsinCD4+andCD8+subsetsinhealthandHIVinfection.HIVwasassociatedwithincreasedproportions ofactivated/terminallydifferentiatedCD1272132+T-cells.IncontrasttoCD127+1322T-cells,CD1272132+T-cellswereKi- 67+Bcl-2 sjTRECs. low and contained increased levels of HIV-DNA. Na?¨ve CD127+1322 T-cells contained a higher proportion of Conclusion:ThelossofCD127fromtheT-cellsurfaceinHIVinfectionisdrivenbyactivationofCD127+1322recentthymic emigrants into CD1272132+ activated/terminally differentiated cells. This process likely results in an irreversible loss of CD127andpermanentdistortionofT-cellhomeostasis. Citation:SassonSC,ZaundersJJ,SeddikiN,BaileyM,McBrideK,etal.(2012)ProgressiveActivationofCD127+1322RecentThymicEmigrantsintoTerminally DifferentiatedCD1272132+T-Cellsi

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