Proinflammatory cytokines tumor necrosis factor-α and interferon-γ modulate epithelial barrier function in Madin-Darby canine kidney cells through mitogen activated protein kinase signaling 英文参考文献.docVIP

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Proinflammatory cytokines tumor necrosis factor-α and interferon-γ modulate epithelial barrier function in Madin-Darby canine kidney cells through mitogen activated protein kinase signaling 英文参考文献.doc

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Proinflammatory cytokines tumor necrosis factor-α and interferon-γ modulate epithelial barrier function in Madin-Darby canine kidney cells through mitogen activated protein kinase signaling 英文参考文献

BMC Physiology BioMedCentral Research article Open Access Proinflammatory cytokines tumor necrosis factor-α and interferon-γ modulate epithelial barrier function in Madin-Darby canine kidney cells through mitogen activated protein kinase signaling David M Patrick1, Amanda K Leone1, Jeffry J Shellenberger2, Kara A Dudowicz3 and Jonathan M King*3 Address: 1Southwestern Graduate School of Biomedical Sciences, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390- 9004, USA, 2UT Medical School, UTHSCSA, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA and 3Trinity University, Biology Department, One Trinity Place, San Antonio, TX 78212, USA Email: David M Patrick - David.Patrick@UTS; Amanda K Leone - Amanda.leone@; Jeffry J Shellenberger - SHELLENBERGE@; Kara A Dudowicz - kara.dudowicz@; Jonathan M King* - jking@ * Corresponding author Published: 21 February 2006 Received: 25 October 2005 Accepted: 21 February 2006 BMC Physiology 2006, 6:2 doi:10.1186/1472-6793-6-2 This article is available from: /1472-6793/6/2 ? 2006 Patrick et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: The tight junction is a dynamic structure that is regulated by a number of cellular signaling processes. Occludin, claudin-1, claudin-2 and claudin-3 are integral membrane proteins found in the tight junction of MDCK cells. These proteins are restricted to this region of the membrane by a complex array of intracellular proteins which are tethered to the cytoskeleton. Alteration of these tight junction protein complexes during pathological events leads to impaired epithelial barrier function that perturbs water and electrolyte homeostasis. We examined MDCK cell barrier functi