Profiling RE1REST-mediated histone modifications in the human genome 英文参考文献.docVIP

Open Access Re 2009ZhengetVoal.lumesea10,rchIssue 1, Article R9 Profiling RE1/REST-mediated histone modifications in the human genome Deyou Zheng*?, Keji Zhao? and Mark F Mehler*§ Addresses: *Institute for Brain Disorders and Neural Regeneration, Department of Neurology, Rose F Kennedy Center for the Study of Intellectual and Developmental Disabilities, Albert Einstein College of Medicine, Morris Park Avenue, Bronx, NY 10461, USA. ?Department of Genetics and Neuroscience, Albert Einstein College of Medicine, Morris Park Avenue, Bronx, NY 10461, USA. ?Laboratory of Molecular Immunology, National Heart, Lung and Blood Institute, National Institute of Health, Rockville Pike, Bethesda, MD 20892, USA. §Departments of Neuroscience, and Psychiatry and Behavioral Sciences, Einstein Cancer Center, Albert Einstein College of Medicine, Morris Park Avenue, Bronx, NY 10461, USA. Correspondence: Deyou Zheng. Email: dzheng@ Published: 27 January 2009 Received: 24 November 2008 Accepted: 27 January 2009 Genome Biology 2009, 10:R9 (doi:10.1186/gb-2009-10-1-r9) The electronic version of this article is the complete one and can be found online at /2009/10/1/R9 ? 2009 Zheng et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: The transcriptional repressor REST (RE1 silencing transcription factor, also called NRSF for neuron-restrictive silencing factor) binds to a conserved RE1 motif and represses many neuronal genes in non-neuronal cells. This transcriptional regulation is transacted by several nucleosome-modifying enzymes recruited by REST to RE1 sites, including histone deacetylases (for example, HDAC1/2), demethylases (for example, LSD1), and methyltransferases (for example, G9a). Results: W