Projecting the Long-Term Impact of School- or Community-Based Mass-Treatment Interventions for Control of Schistosoma Infection 英文参考文献.docVIP

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Projecting the Long-Term Impact of School- or Community-Based Mass-Treatment Interventions for Control of Schistosoma Infection 英文参考文献.doc

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Projecting the Long-Term Impact of School- or Community-Based Mass-Treatment Interventions for Control of Schistosoma Infection 英文参考文献

ProjectingtheLong-TermImpactofSchool-or Community-BasedMass-TreatmentInterventionsfor ControlofSchistosomaInfection XiaoxiaWang1,DavidGurarie1,PeterL.Mungai2,EricM.Muchiri3,UrielKitron4,CharlesH.King2,5* 1DepartmentofMathematics,CaseWesternReserveUniversity,Cleveland,Ohio,UnitedStatesofAmerica,2CenterforGlobalHealthandDiseases,CaseWesternReserve University,Cleveland,Ohio,UnitedStatesofAmerica,3DivisionofVectorBorneandNeglectedTropicalDiseases,MinistryofPublicHealthandSanitation,Nairobi,Kenya, 4Department of Environmental Sciences, Emory University, Atlanta, Georgia, United States of America, 5Schistosomiasis Consortium for Research and Evaluation, UniversityofGeorgia,Athens,Georgia,UnitedStatesofAmerica Abstract Background:Schistosomiasisremainsasignificanthealthburdeninmanyareasoftheworld.Morbiditycontrol,focusedon limitinginfectionintensitythroughperiodicdeliveryofanti-schistosomalmedicines,isthethrustofcurrentWorldHealth Organizationguidelines(2006)forreductionofSchistosoma-relateddisease.Anewappreciationofthelifetimeimpactof repeatedSchistosomainfectionhasdirectedattentiontowardstrategiesforgreatersuppressionofparasiteinfectionperse, with the goal of transmission interruption. Variations in drug schedules involving increased population coverage and/or treatment frequency are now undergoing field trials. However, their relative effectiveness in long-term infection suppressionispresentlyunknown. Methodology/PrincipalFindings:Ourstudyusedavailablefielddatatocalibrateadvancednetworkmodelsofvillage-level Schistosomatransmissiontoprojectoutcomesofsixdifferentcommunity-orschoolage-basedprograms,ascomparedto theimpactofcurrent2006W.H.O.recommendedcontrolstrategies.Wethenscoredthenumberofyearseachof10typical villageswouldremainbelow10%infectionprevalence(apracticablelevelassociatedwithminimalprevalenceofdisease). All strategies that included four annual treatments effectively reduced community prevalence to less than 10%, while programshavingyearlygaps(‘holidays’)fail