Protection against Recurrent Stroke with Resveratrol Endothelial Protection 英文参考文献.docVIP

Protection against Recurrent Stroke with Resveratrol Endothelial Protection 英文参考文献.doc

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Protection against Recurrent Stroke with Resveratrol Endothelial Protection 英文参考文献

ProtectionagainstRecurrentStrokewithResveratrol: EndothelialProtection DarrenClark1,2,3,UrsulaI.Tuor1,2*,RogerThompson2,AdamInstitoris4,AngelaKulynych2,XuZhang6, DavidW.Kinniburgh6,FerencBari3,DavidW.Busija5,PhilipA.Barber2 1DepartmentsofPhysiologyandPharmacology,ClinicalNeurosciencesandRadiology,UniversityofCalgary,Calgary,Canada,2HotchkissBrainInstituteandFacultyof Medicine,UniversityofCalgary,Calgary,Canada,3DepartmentofMedicalPhysicsandInformatics,UniversityofSzeged,Szeged,Hungary,4DepartmentofPhysiology, University of Szeged, Szeged, Hungary, 5Department of Pharmacology, Tulane University, New Orleans, Louisiana, United States of America, 6Alberta Centre for Toxicology,UniversityofCalgary,Calgary,Canada Abstract Despite increased risk of a recurrent stroke following a minor stroke, information is minimal regarding the interaction betweeninjuriousmildcerebralischemicepisodesandthepossibletreatmentswhichmightbeeffective.Theaimofthe currentstudywastoinvestigaterecurrentischemicstrokeandwhetherresveratrol,anutritivepolyphenolwithpromising cardio- and neuro- protective properties, could ameliorate the associated brain damage. Experiments in adult rats demonstrated that a mild ischemic stroke followed by a second mild cerebral ischemia exacerbated brain damage, and, dailyoralresveratroltreatmentafterthefirstischemicinsultreducedischemiccelldeathwiththerecurrentinsult(P,0.002). Furtherinvestigationdemonstratedreductionofbothinflammatorychangesandmarkersofoxidativestressinresveratrol treated animals. The protection observed with resveratrol treatment could not be explained by systemic effects of resveratroltreatmentincludingeffectseitheronbloodpressureorbodytemperaturemeasuredtelemetrically.Investigation ofresveratroleffectsontheblood-brainbarrierinvivodemonstratedthatresveratroltreatmentreducedblood-brainbarrier disruption and edema following recurrent stroke without affecting regional cerebral blood flow. Investigation of the mechanisminprimarycellculturestudiesdem

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