- 1、本文档共11页,可阅读全部内容。
- 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
- 5、该文档为VIP文档,如果想要下载,成为VIP会员后,下载免费。
- 6、成为VIP后,下载本文档将扣除1次下载权益。下载后,不支持退款、换文档。如有疑问请联系我们。
- 7、成为VIP后,您将拥有八大权益,权益包括:VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 8、VIP文档为合作方或网友上传,每下载1次, 网站将根据用户上传文档的质量评分、类型等,对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
Protection against Recurrent Stroke with Resveratrol Endothelial Protection 英文参考文献
ProtectionagainstRecurrentStrokewithResveratrol:
EndothelialProtection
DarrenClark1,2,3,UrsulaI.Tuor1,2*,RogerThompson2,AdamInstitoris4,AngelaKulynych2,XuZhang6,
DavidW.Kinniburgh6,FerencBari3,DavidW.Busija5,PhilipA.Barber2
1DepartmentsofPhysiologyandPharmacology,ClinicalNeurosciencesandRadiology,UniversityofCalgary,Calgary,Canada,2HotchkissBrainInstituteandFacultyof
Medicine,UniversityofCalgary,Calgary,Canada,3DepartmentofMedicalPhysicsandInformatics,UniversityofSzeged,Szeged,Hungary,4DepartmentofPhysiology,
University of Szeged, Szeged, Hungary, 5Department of Pharmacology, Tulane University, New Orleans, Louisiana, United States of America, 6Alberta Centre for
Toxicology,UniversityofCalgary,Calgary,Canada
Abstract
Despite increased risk of a recurrent stroke following a minor stroke, information is minimal regarding the interaction
betweeninjuriousmildcerebralischemicepisodesandthepossibletreatmentswhichmightbeeffective.Theaimofthe
currentstudywastoinvestigaterecurrentischemicstrokeandwhetherresveratrol,anutritivepolyphenolwithpromising
cardio- and neuro- protective properties, could ameliorate the associated brain damage. Experiments in adult rats
demonstrated that a mild ischemic stroke followed by a second mild cerebral ischemia exacerbated brain damage, and,
dailyoralresveratroltreatmentafterthefirstischemicinsultreducedischemiccelldeathwiththerecurrentinsult(P,0.002).
Furtherinvestigationdemonstratedreductionofbothinflammatorychangesandmarkersofoxidativestressinresveratrol
treated animals. The protection observed with resveratrol treatment could not be explained by systemic effects of
resveratroltreatmentincludingeffectseitheronbloodpressureorbodytemperaturemeasuredtelemetrically.Investigation
ofresveratroleffectsontheblood-brainbarrierinvivodemonstratedthatresveratroltreatmentreducedblood-brainbarrier
disruption and edema following recurrent stroke without affecting regional cerebral blood flow. Investigation of the
mechanisminprimarycellculturestudiesdem
您可能关注的文档
- Prophylactic Activated Recombinant Factor VII in Liver Resection and Liver Transplantation Systematic Review and Meta-Analysis 英文参考文献.doc
- Prophylactic antibiotic treatment is superior to therapy on-demand in experimental necrotising pancreatitis 英文参考文献.doc
- 236例系统性红斑狼疮患者血液系统损害特点及免疫检测分析.pdf
- Prophylactic administration of abatacept (CTLA4-Ig; BMS-188667) prevents disease induction and bone destruction in a rat model of collagen-induced arthritis 英文参考文献.doc
- Prophylactic and Therapeutic Efficacy of Human Monoclonal Antibodies against H5N1 Influenza 英文参考文献.doc
- Prophylactic Platelets in Dengue Survey Responses Highlight Lack of an Evidence Base 英文参考文献.doc
- Prophylactic open abdomen in patients with postoperative intra-abdominal hypertension 英文参考文献.doc
- Prophylactic and Therapeutic Vaccination against Hepatitis C Virus (HCV) Developments and Future Perspectives 英文参考文献.doc
- Propionyl-L-carnitine Corrects Metabolic and Cardiovascular Alterations in Diet-Induced Obese Mice and Improves Liver Respiratory Chain Activity 英文参考文献.doc
- Proportion Mendélienne Anormale Pour Le Gène ? Cou Nu ? Chez La Poule Domestique 英文参考文献.doc
- Protection against High-Dose Highly Pathogenic Mucosal SIV Challenge at Very Low Serum Neutralizing Titers of the Antibody-Like Molecule CD4-IgG2 英文参考文献.doc
- Protection against Retrovirus Pathogenesis by SR Protein Inhibitors 英文参考文献.doc
- Protecting Groups in Carbohydrate Chemistry Influence on Stereoselectivity of Glycosylations 英文参考文献.doc
- Protection against Tuberculosis in Eurasian Wild Boar Vaccinated with Heat-Inactivated Mycobacterium bovis 英文参考文献.doc
- Protection against Chlamydia Promoted by a Subunit Vaccine (CTH1) Compared with a Primary Intranasal Infection in a Mouse Genital Challenge Model 英文参考文献.doc
- Protection and Polyfunctional T Cells Induced by Ag85B-TB10.4IC31? against Mycobacterium tuberculosis Is Highly Dependent on the Antigen Dose 英文参考文献.doc
- Protection against Mucosal SHIV Challenge by Peptide and Helper-Dependent Adenovirus Vaccines 英文参考文献.doc
- Protection from Experimental Cerebral Malaria with a Single Dose of Radiation-Attenuated, Blood-Stage Plasmodium berghei Parasites 英文参考文献.doc
- Protection by Anti-β-Glucan Antibodies Is Associated with Restricted β-1,3 Glucan Binding Specificity and Inhibition of Fungal Growth and Adherence 英文参考文献.doc
- Protection against Mycobacterium ulcerans Lesion Development by Exposure to Aquatic Insect Saliva 英文参考文献.doc
文档评论(0)