Protection against Mucosal SHIV Challenge by Peptide and Helper-Dependent Adenovirus Vaccines 英文参考文献.docVIP

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Protection against Mucosal SHIV Challenge by Peptide and Helper-Dependent Adenovirus Vaccines 英文参考文献.doc

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Protection against Mucosal SHIV Challenge by Peptide and Helper-Dependent Adenovirus Vaccines 英文参考文献

Viruses 2009, 1, 920-938; doi:10.3390/v1030920 OPEN ACCESS viruses ISSN 1999-4915 /journal/viruses Article Protection against Mucosal SHIV Challenge by Peptide and Helper-Dependent Adenovirus Vaccines Eric A. Weaver 1,#, Pramod N. Nehete 2,#, Bharti P. Nehete 2, Stephanie J. Buchl 2, Donna Palmer 3, David C. Montefiori 4, Philip Ng 3, K. Jagannadha Sastry 2,5 and Michael A. Barry 1,6,7, * 1 Department of Internal Medicine, Division of Infectious Diseases, Translational Immunovirology Program, Mayo Clinic, Rochester, MN 55905, USA 2 3 Department of Veterinary Sciences, M.D. Anderson Cancer Center, The University of Texas, Bastrop, TX 78602, USA Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA 4 5 Duke University Medical Center, Durham, NC 27710, USA Department of Immunology, M.D. Anderson Cancer Center, The University of Texas, Houston, TX 77054, USA 6 7 Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA Department of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA * Author to whom correspondence should be addressed; E-mail: mab@; Tel: +1-507-266-9090; Fax: +1-507-255-2811. # These authors contributed equally to this work. Received: 5 October 2009; in revised form: 6 November 2009 / Accepted: 9 November 2009 / Published: 10 November 2009 Abstract: Groups of rhesus macaques that had previously been immunized with HIV-1 envelope (env) peptides and first generation adenovirus serotype 5 (FG-Ad5) vaccines expressing the same peptides were immunized intramuscularly three times with helper- dependent adenovirus (HD-Ad) vaccines expressing only the HIV-1 envelope from JRFL. No gag, pol, or other SHIV genes were used for vaccination. One group of the FG-Ad5- immune animals was immunized three times with HD-Ad5 expressing env. One group was immunized by serotype-switching with HD-Ad6, HD-Ad1, and HD-Ad2 expressing env. Previous work demonstrated that seru